Eremophilane Sesquiterpene Lactones from Ligularia virgaurea ssp. oligocephala

Abstract

From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10α-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6α,10α-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6β,10β-dihydroxyeremophila-7(11),8(9)-dien-12,8-olide (3), as well as four known sesquiterpene lactones with the same carbon skeleton, named toluccanolides A - C (4, 5, 7) and 6β-hydroxy-8α-methoxyeremophila-1(10),7(11)-dien-12,8β-olide (6) were isolated. Their structures were elucidated by spectroscopic methods including intensive 2D NMR techniques (gCOSY, gHMQC, gHMBC and ¹H-¹H NOESY for 2) and HR-ESI-MS.

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