Cytotoxic Alkaloids from the Roots of Tylophora atrofolliculata

Abstract

Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC₅₀ values in the range 0.083 to 18.99 μM) and KB cell (in the range 3.56 to 18.22 μM) lines.

Key words

Tylophora atrofolliculata - Asclepiadaceae - phenanthroindolizidine alkaloids - tylophoridicines C-F - cytotoxicity

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