Planta Med 2004; 70(5): 441-445
DOI: 10.1055/s-2004-818973
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Alkaloids from the Roots of Tylophora atrofolliculata

Xueshi Huang1 , Song Gao1 , Lihua Fan1 , Shishan Yu1 , Xiaotian Liang1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
The research was supported by National 973 Project (No.G1998-051120)
Further Information

Publication History

Received: September 22, 2003

Accepted: March 3, 2004

Publication Date:
04 May 2004 (online)

Abstract

Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 μM) and KB cell (in the range 3.56 to 18.22 μM) lines.

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Prof. Dr. Shishan Yu

Institute of Materia Medica

Chinese Academy of Medical Sciences & Peking Union Medical College

No.1 Xiannongtan Street

Beijing 100050

People's Republic of China

Phone: +86-10-63165324

Fax: +86-10-63017757

Email: yushishan@imm.ac.cn