Download PDF
Cent Eur Neurosurg 2004; 65(3): 141-145
DOI: 10.1055/s-2004-816241
Case Report

© Georg Thieme Verlag Stuttgart · New York

Multiple Metastatic Malignant Meningioma: A Case Report

Multipel metastasierendes malignes Meningiom: FallberichtS. Dogan1 , S. Sahin1 , O. Taskapılıoglu1 , K. Aksoy1 , S. Adım2
  • 1Department of Neurosurgery, School of Medicine, Uludag University, Bursa, Turkey
  • 2Department of Pathology, School of Medicine, Uludag University, Bursa, Turkey
Further Information

Publication History

Publication Date:
12 August 2004 (online)

    Permissions and Reprints

Abstract

We report a case of a 27-year-old man who presented with a clinical history of swelling on the left side of his head. MRI scan showed a left frontal meningioma. The patient underwent a macroscopically complete resection. The histological diagnosis was malignant meningioma. Ten months after the initial diagnosis, multiple distant metastases were detected. Risk factors leading to metastasis in this case are discussed with a review of the literature.

Zusammenfassung

Wir berichten über einen 27-jährigen männlichen Patienten, der mit einer Schwellung auf der rechten Kopfseite vorgestellt wurde. Die MRI-Aufnahmen zeigten ein links frontal liegendes Meningioma. Bei dem Patienten wurde eine makroskopisch komplette Resektion durchgeführt. Die histologische Diagnose lautete malignantes Meningioma. Zehn Monate nach der anfänglichen Diagnose wurden mehrere entfernte Metastasen festgestellt. Unter Berücksichtigung der Literatur wurden die Risikofaktoren, die in diesem Fall zu Metastasen führten, diskutiert.

Key words

Malignant meningioma - metastasis - brain tumor

Schlüsselwörter

Malignantes Meningioma - Metastasis - Kopftumor

References

  • 1 Adlakha A, Rao K, Adlakha H, Perry A, Crotty T. et al . Meningioma matastatic to the lung.  Mayo Clin Proc. 1999;  74 1129-1133
    CrossrefPubMedGoogle Scholar
  • 2 Akeyson E W, McCutcheon I E. Management of benign and aggressive intracranial meningiomas.  Oncol. 1996;  10 747-756
    PubMedGoogle Scholar
  • 3 Celli P, Palma L, Domenicucci M, Scarpinati M. Histologically benign recurrent meningioma metastasizing to the parotid gland: case report and review of the literature.  Neurosurgery. 1992;  31 1113-1116
    CrossrefPubMedGoogle Scholar
  • 4 DeMonte F, Marmor E, Al Mefty O. Meningiomas. In: Kaye AH, Laws ER (eds). Brain Tumours. Churchill Livingstone, Edinburgh 2001; 720-746
    Google Scholar
  • 5 De Ridder L, Calliauw L. Invasiveness of primary and secondary brain tumours in vitro correlated with clinical results.  Neurosurgery. 1992;  31 1043-1048
    PubMedGoogle Scholar
  • 6 Drummond K J, Bittar R G, Fearnside M R. Metastatic atypical meningioma: case report and review of the literature.  J Clin Neuroscience. 2000;  7 69-72
    PubMedGoogle Scholar
  • 7 Enam A S, Abdulrauf S, Mehta B. et al . Metastasis in meningioma.  Acta Neurochir. 1996;  138 1172-1178
    CrossrefPubMedGoogle Scholar
  • 8 Fukushima T, Tsugu H, Tomonaja M, Shirakusa T. Papillary meningioma with pulmonary metastasis.  J Neurosurg. 1989;  70 478-482
    CrossrefPubMedGoogle Scholar
  • 9 Kaba S E, DeMonte F, Brunner J, Kyritsis A, Kurt J. et al . The treatment of recurrent unresectable and malignant meningiomas with interferon alpha-2B clinical study.  Neurosurgery. 1997;  40 271-275
    CrossrefPubMedGoogle Scholar
  • 10 Kros J M, Cella F, Bakker S LM, Paz Y, Geuze D, Egeler R M. Papillary meningioma with pleural metastasis: case report and literature review.  Acta Neurol Scan. 2000;  102 200-202
    PubMedGoogle Scholar
  • 11 Lee K S, Hoshino T, Rodriguez L A, Bederson J, Davis R L, Wilson C B. Bromodeoxyuridine labeling study of intracranial meningiomas: proliferative potential and recurrence.  Acta Neuropathol. 1990;  80 311-317
    CrossrefPubMedGoogle Scholar
  • 12 LeMay D R, Bucci M N, Farhat S M. Malignant transformation of recurrent meningioma with pulmonary metastases.  Surg Neurol. 1989;  31 365-368
    PubMedGoogle Scholar
  • 13 New P F, Hesselink J R, O'Corroll C P, Kleinman G M. Malignant meningiomas. CT and histologic criteria, including a new CT sign.  AJNR. 1982;  3 267-276
    PubMedGoogle Scholar
  • 14 Ng T, Wong M P, Chan K W. Benign metastasizing meningioma.  Clin Neurol Neurosurg. 1990;  92 152-154
    CrossrefPubMedGoogle Scholar
  • 15 Ohta M, Iwaki T, Kitamoto T, Takeshita I. et al . MIB-1 staining index and scoring of histological in meningioma.  Cancer. 1994;  74 3176-3189
    PubMedGoogle Scholar
  • 16 Prayson R A. Malignant meningioma: a clinicopathologic study of 23 patients including MIB1 and p53 immunohistochemstry.  Am J Clin Pathol. 1996;  105 719-726
    PubMedGoogle Scholar
  • 17 Shuangshoti S, Hongsaprabhas C, Nersky M G. Metastasizing meningioma.  Cancer. 1970;  26 832-841
    PubMedGoogle Scholar
  • 18 Slavin M L. Metastatic malignant meningioma.  J Clin Neuro-Ophthalmology. 1989;  9 55-59
    PubMedGoogle Scholar
  • 19 Strang R R, Tovi D, Nordenstam H. Meningioma with intracerebral, cerebellar and visceral metastases.  J Neurosurg. 1964;  21 1098-1102
    PubMedGoogle Scholar
  • 20 Tao L iang-Che. Pulmonary metastases from intracranial meningioma diagnosed by aspiration biopsy cytology.  Acta Cytology. 1991;  35 524-528
    PubMedGoogle Scholar
  • 21 Travitzky M, Libson E, Nemirovsky I, Gabizon A. Doxil induced regression of pleuro-pulmonary metastases in a patient with malignant meningioma.  Anticancer Drugs. 2003;  14 247-250
    CrossrefPubMedGoogle Scholar
  • 22 Tworek J A, Mikhail A A, Blaivas M. Meningioma: Local recurrence and pulmonary metastasis diagnosed by fine needle aspiration.  Acta Cytologia. 1997;  41 946-947
    PubMedGoogle Scholar
  • 23 Tytus J S, Lasersohn J T, Reifel E. The problem of malignancy in meningiomas.  J Neurosurg. 1967;  27 551-557
    PubMedGoogle Scholar
  • 24 Ueyama Y, Marita K, Ochiai C, Ohsawa N, Hata J, Tamaoki N. Xenotransplantation of a human meningioma and its lung metastasis in nude mice.  Br J Cancer. 1978;  37 644-647
    PubMedGoogle Scholar
  • 25 Younis G A, Sawaya R, Demonte F, Hess K R, Albrecht S, Bruner J M. Aggressive meningeal tumors: review of a series.  J Neurosurg. 1995;  82 17-27
    PubMedGoogle Scholar
  • 26 Zorludemir S, Scheithauer B W, Hirose T, Van Houten C, Miller G, Meyer F B. Clear cell meningioma. A clinicopathological study of a potentially aggressive variant of meningioma.  Am J Surg Pathol. 1995;  19 493-505
    CrossrefPubMedGoogle Scholar

Seref DoganM.D. 

Uludag University

School of Medicine

Department of Neurosurgery

Gorukle, 16059 Bursa

Turkey

Phone: +90/2 24-4 42 80 81

Fax: +90/2 24-4 42 92 63

Email: sdogan@uludag.edu.tr