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Synthesis 2004(4): 610-618
DOI: 10.1055/s-2004-815947
DOI: 10.1055/s-2004-815947
PAPER
© Georg Thieme Verlag Stuttgart · New York
Gold(III)-Catalyzed Annulation of 2-Alkynylanilines: A Mild and Efficient Synthesis of Indoles and 3-Haloindoles
Weitere Informationen
Received
23 December 2003
Publikationsdatum:
03. Februar 2004 (online)
Publikationsverlauf
Publikationsdatum:
03. Februar 2004 (online)
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Abstract
Gold(III)-catalyzed annulation of 2-alkynylanilines in EtOH or EtOH-water mixtures at room temperature gives indoles derivatives in good yields. One-flask protocol for the gold-catalyzed conversion of 2-alkynylanilines to 3-bromo and 3-iodoindoles is also reported.
Key words
2-alkynylanilines - indoles - 5-endo-dig cyclization - gold catalysis - halogenations
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