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DOI: 10.1055/s-2004-815541
© Georg Thieme Verlag Stuttgart · New York
New Eremophilane-Type Sesquiterpenes from Ligularia lapathifolia
This research was financially supported by the Natural Science Foundation (NSFC) for outstanding young scientists for Wang Z. T. (39 825 129)Publication History
Received: July 28, 2003
Accepted: December 12, 2003
Publication Date:
23 March 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200403/lookinside/thumbnails/10.1055-s-2004-815541-1.jpg)
Abstract
Seven new eremophilanolides were isolated from the roots and rhizomes of Ligularia lapathifolia. Their structures were established as 3β-angeloyloxy-8βH-eremophil-7(11)-ene-12,8α (14β, 6α)-diolide, 3β-angeloyloxy-8β-hydroxyeremophil-7(11)-ene-12,8α(14β,6α)-diolide,3β-angeloyloxy-8β-methoxyeremophil- 7(11)-ene-12,8α(14β,6α)-diolide,3β-angeloyloxy-8β-ethoxyeremophil-7(11)-ene-12, 8α (14β,6α)-diolide, 3β-angeloyloxy-10β- hydroxyeremophil-8(9),7(11)-diene-12,8(14β,6α)-diolide, 3β-angeloyloxy-8,12-expoy-12α-hydroxy-8β-methoxyeremophil-7(11)-en-14β,6α-olide and 3β-angeloyloxyeremophilan-7,11-dien-14β,6α-olide, by means of spectroscopic analyses. Moreover, application of a photooxygenation reaction on 7 resulted in the generation of 2 with an α,β-unsaturated γ-lactone moiety. This biomimetic transformation supports a biogenetic pathway proposed for 2.
Key words
Ligularia lapathifolia - Asteraceae - eremophilane-type sesquiterpenes - photooxygenation
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Dr. Yun-sen Li
State Key Laboratory of Drug Research
Shanghai Institute of Materia Medica
Chinese Academy of Sciences
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