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DOI: 10.1055/s-2004-815540
© Georg Thieme Verlag Stuttgart · New York
New Lignans and Cytotoxic Constituents from Wikstroemia lanceolata
This research was financially supported by the National Science Council of the Republic of ChinaPublication History
Received: July 10, 2003
Accepted: November 22, 2003
Publication Date:
23 March 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200403/lookinside/thumbnails/10.1055-s-2004-815540-1.jpg)
Abstract
Two new lignans, (-)-aptosimon (1) and (-)-diasesamin-di-γ-lactone (2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1α,7α,10αH-guaia-4,11-dien-3-one (24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin (6), 2,6-dimethoxy-p-benzoquinone (17), and 1α,7α,10αH-guaia-4,11-dien-3-one (24) exhibited effective cytotoxicities (ED50 values < 4.0 μg mL-1) against P-388 and HT-29 tumor cell lines.
Key words
Wikstroemia lanceolata - Thymelaeaceae - stem - root - lignans - aptosimon - diasesamin-di-γ-lactone - sesquiterpenoids - cytotoxicity
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Prof. Dr. I. S. Chen
Graduate Institute of Natural Products
Kaohsiung Medical University
Kaohsiung
Taiwan 807
Republic of China
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Email: m635013@kmu.edu.tw