Der Nuklearmediziner 2003; 26(4): 285-291
DOI: 10.1055/s-2003-44825
Multimodale Bildgebung

© Georg Thieme Verlag Stuttgart · New York

Funktionelle Bildgebung mit [F-18]FDG bei Kopf-Hals-Tumoren: Korrelation mit morphologischen Methoden

Functional Imaging with [F-18]FDG of Head and Neck Tumors: Correlation with Morphological Methods S. Dresel1 , K. Schwenzer2
  • 1Klinik und Poliklinik für Nuklearmedizin, Ludwig-Maximilians-Universität, München
  • 2Klinik für Mund-Kiefer-Gesichtschirurgie, Ludwig-Maximilians-Universität, München
Further Information

Publication History

Publication Date:
19 December 2003 (online)

Zusammenfassung

In der Diagnostik von Kopf-Hals-Tumoren ist die FDG-PET nach derzeitigem Stand der Literatur und nach eigenen Erfahrungen der CT in der Diagnostik der Primär-/Rezidivtumoren und in der Diagnostik zervikaler Lymphknotenmetastsasen überlegen. Dies gilt auch für die Diagnostik von Fernmetastasen oder die Detektion von Zweittumoren, die bei typischem Patientengut überhäufig auftreten. Für die exakte Interpretation der in der PET erhobenen Befunde ist jedoch die Korrelation mit der morphologischen Bildgebung sinnvoll und notwendig. Die Bildkorrelation verbindet hierbei die Vorteile der funktionellen und der morphologischen Methodik ohne wesentlichen zusätzlichen Aufwand, da PET und CT im Rahmen des Stagings durchgeführt werden. Diese Methodik erlaubt eine bessere anatomische Zuordnung der PET Befunde und eine bessere Differenzierung der im CT auffälligen Befunde. In einem klinischen Umfeld sollte die Bildkorrelation zur Verbesserung der diagnostischen Aussagekraft routinemäßig bei Tumoren der Kopf-Hals-Region durchgeführt werden. Auf eine exakte Fusion der Datensätze kann in den meisten Fällen verzichtet werden; diese bleibt problematischen Situationen mit unklaren anatomischen Verhältnissen vorbehalten.

Abstract

In the diagnosis of tumors of the head and neck FDG-PET is according to the literature superior to CT in terms of diagnosing primary and recurrent tumors as well as cervical lymph node spread. FDG-PET is also better in detecting distant metastatic disease and in screening for secondary malignant lesion which are rather common in this patient group. However, correlation of the findings with morphological methods such as CT is crucial. Image correlation combines the advantages inherent to both, functional and morphological methods, without sacrificing too much time, since both methods are included in most staging protocols. This approach allows for better anatomical correlation of PET findings and an improved differentiation of the CT results. In a clinical setting image correlation should routinely be performed to increase diagnostic accuracy and efficiency. A very exact fusion of both data sets, however, is in most circumstances dispensable and may only be necessary in exceedingly complex anatomical situations.

Literatur

  • 1 Abdel-Nabi H, Spaulding M B, Behar P, Nguyen A, Simpson G, Gona J. Value of PET-FDG imaging in the pre-operative work-up of patients with head and neck carcinomas.  J Nucl Med. 1996;  37 136
  • 2 Ali S, Tiwar R M, Snow G B. False positive and false-negative neck nodes.  Head Neck Surg. 1985;  8 78-82
  • 3 Anzai Y, Carroll W R, Quint D J, Bradford C R, Minoshima S, Wolf G T, Wahl R L. Recurrence of head and neck cancer after surgery or irradiation: prospective comparison of 2- deoxy-2[F-18]-fluoro-D-glucose PET and MR imaging diagnosis.  Radiology. 1996;  200 135-141
  • 4 Bailet J W, Abemayor E, Jabour B A, Hawkins R A, Hoh C, Ward P H. Positron emission tomography: a new, precise imaging modality for detection of primary head and neck tumours and assessment of cervical adenopathy.  Laryngoscope. 1992;  102 281-288
  • 5 Braams J W, Pruim J, Freling N JM, Nikkels P G, Roodenburg J L, Boering G, Vaalburg W, Vermey A. Detection of lymph node metastases of squamous-cell cancer of the head and neck with FDG-PET and MRI.  J Nucl Med. 1995;  36 211-216
  • 6 Braams J W, Pruim J, Kole A C, Nikkels P G, Vaalburg W, Vermey A, Roodenburg J L. Detection of unknown primary head and neck tumours by positron emissions tomography.  Int J Oral Maxillofac Surg. 1997;  26 112-115
  • 7 Bronstein A D, Nyberg D A, Schwartz A N, Schumann W P, Griffin B R. Soft tissue changes after head and neck radiation: CT findings.  Am J Neurol Rad. 1989;  10 171-175
  • 8 Dillon W P, Harnsberger H R. The impact of radiologic imaging on staging of cancer of the head and neck.  Semin Oncol. 1991;  18 64-79
  • 9 Dresel S, Grammerstorff J, Schwenzer K, Brinkbaumer K, Schmid R, Pfluger T, Hahn K. [(18)F]FDG imaging of head and neck tumours: comparison of hybrid PET and morphological methods.  Eur J Nucl Med Mol Imaging. 2003;  30 (7) 995-1003
  • 10 Engel H, Steinert H, Buck A, Berthold T, Boni A H, von Schulthess G K. Whole-body PET: physiological and artifactual fluordeoxyglucose accumulations.  J Nucl Med. 1996;  37 441-446
  • 11 Haberkorn U, Strauss L G, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, Oberdorfer F, Rudat V, van Kaick G. Glucose uptake, perfusion and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry.  J Nucl Med. 1991;  32 1548-1555
  • 12 Harnsberger H, Mancuso A, Muraki A, Parkin J. The upper aerodigestive tract and neck: CT evaluation of recurrent tumors.  Radiology. 1983;  149 403-409
  • 13 Hillsamer P J, Schuller D E, Mc Ghee R B, Chakeres D, Young D C. Improving diagnostic accuracy of cervical metastases with computed tomography and magnetic resonance imaging.  Arch Otolaryngol Head Neck Surg. 1990;  116 1297-1301
  • 14 Jabour B A, Choi Y, Hoh C K, Rege S D, Soong J C, Lufkin R B, Hanafee W N, Maddahi J, Chaiken L, Bailet J. Extracranial head and neck: PET imaging with 2-[F-18] fluoro-2-deoxy-D-glucose and MR imaging correlation.  Radiology. 1993;  186 27-35
  • 15 Jungehülsing M, Scheidhauer K, Damm M, Pietrzyk U, Eckel H, Schicha H, Stennert E. 2[F]-fluoro-2-deoxy-D-glucose positron emission tomography is a sensitive tool for the detection of occult.  Otolaryngol Head Neck Surg. 2000;  123 294-301
  • 16 Lapela M, Grenman R, Kurki T, Joensuu H, Leskinen S, Lindholm P, Haaparanta M, Ruotsalainen U, Minn H. Head and neck cancer: detection of recurrence with PET and 2-[F18]fluoro-2-deoxy-D-glucose.  Radiology. 1995;  197 205-211
  • 17 Laubenbacher C, Saumweber D, Wagner-Manslau C, Kau R J, Herz M, Avril N, Ziegler S, Kruschke C, Arnold W, Schwaiger M. Comparison of fluorine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas.  J Nucl Med. 1995;  36 1747-1757
  • 18 Mc Guirt W F, Williams D W, Keyes J W, Greven K M, Watson N E, Geisinger K R, Cappellari J O. A comparative diagnostic study of head and neck nodal metastases using positron emission tomography.  Laryngoscope. 1995;  105 373-375
  • 19 Minn H, Clavo A C, Grenman R, Wahl R L. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck.  J Nucl Med. 1995;  36 252-258
  • 20 Minn H, Joensuu H, Ahonen A, Klemi P. Fluorodeoxyglucose imaging: a method to assess the proliferative activity of human cancer in vivo.  Cancer. 1988;  61 1776-1781
  • 21 Nowak B, Di Martino E, Jänicke S, Cremerius U, Adam G, Zimny M, Reinartz P, Büll U. Diagnostic evaluation of malignant head and neck cancer by F-18-FDG PET compared to CT/MRI.  Nuklearmedizin. 1999;  38 312-318
  • 22 Pfluger T, Vollmar C, Wismuller A, Dresel S, Berger F, Suntheim P, Leinsinger G, Hahn K. Quantitative comparison of automatic and interactive methods for MRI-SPECT image registration of the brain based on 3-dimensional calculation of error.  J Nucl Med. 2000;  41 1823-1829
  • 23 Quetz J U, Rohr S, Hoffmann P, Wustrow J, Mertens J. B-image sonography in lymph node staging of the head and neck area. A comparison with palpation, computerized and magnetic resonance tomography.  HNO. 1991;  39 61-63
  • 24 Shah J P. Cervical lymph node metastases-diagnostic, therapeutic and prognostic implications.  Oncology. 1990;  4 61-69
  • 25 Stokkel M PM, ten Broek F W, van Rijk P P. Preoperative assessment of cervical lymph nodes in head and neck cancer with fluorine-18 fluorodeoxyglucose using a dual-head coincidence camera: a pilot study.  Eur J Nucl Med. 1999;  26 499-503
  • 26 Stokkel M PM, Terhaard C HJ, Hordijk G J, van Rijk P P. The detection of local recurrent head and neck cancer with fluroine-18 fluorodeoxyglucose dual-head positron emission tomography.  Eur J Nucl Med. 1999;  26 767-773
  • 27 Stokkel M PM, van Isselt J W, Hoekstra A, van Rijk P P. Lesions of 4 mm and 5 mm detected with 18F-FDG using a dual head coincidence camera [abstract].  Eur J Nucl Med. 1998;  25 1032
  • 28 van den Brekel M WM, Catelijns J A, Croll G A, Stel H V, Valk J, van der Waal I, Golding R P, Meyer C J, Snow G B. Magnetic resonance imaging versus palpation of cervical lymph node metastases.  Arch Otolaryngol Head Neck Surg. 1991;  117 666-673
  • 29 van den Brekel M WM, Stel H V, Castelijns J A, Nauta J J, van der Waal I, Valk J, Meyer C J, Snow G B. Cervical lymph node metastasis: assessment of radiologic criteria.  Radiology. 1990;  177 379-384

Priv.-Doz. Dr. med. S Dresel

Klinik und Poliklinik für Nuklearmedizin

Ludwig-Maximilians-Universität

Ziemssenstr. 1

80336 München

Phone: 0 89-51 60-24 43

Fax: 0 89-51 60-44 88

Email: dresel@nuk.med.uni-muenchen.de