Rheological Abnormalities and Thromboembolic Complications in Heart Disease: Spontaneous Echo Contrast and Red Cell Aggregation

Hau C. Kwaan; Shumpei Sakurai; Jun Wang

doi:10.1055/s-2003-44559

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Semin Thromb Hemost 2003; 29(5): 529-534
DOI: 10.1055/s-2003-44559

Rheological Abnormalities and Thromboembolic Complications in Heart Disease: Spontaneous Echo Contrast and Red Cell Aggregation

Hau C. Kwaan^1,2 , Shumpei Sakurai ³ , Jun Wang ²

¹Professor of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
²Hematology and Oncology Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
³Matsumoto General Hospital, Matsumoto, Japan

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Publication Date:
21 November 2003 (online)

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ABSTRACT

The role of abnormal rheological changes in the pathogenesis of thromboembolism has received much attention in recent years, especially in the field of cardiology. Such changes are sometimes seen in an echocardiogram as a smokelike haze known as spontaneous echo contrast (SEC). The presence and severity of SEC correlate with dilated cardiac chambers and the incidence of thromboembolic complications. It is caused by increased red cell aggregation and increased fibrinogen levels, both of which are known risk factors for thrombosis. Although not used clinically, measurements of red cell aggregation can be made in research settings. This can provide findings that give insight into factors causing increased red cell aggregation. A small series of patients with angina pectoris was studied with the Myrenne aggregometer for red cell aggregation. The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. As yet, there are only a few therapeutic guidelines for the correction of abnormally high fibrinogen levels in patients at risk.

KEYWORDS

Fibrinogen - red cell aggregation - spontaneous echo contrast - viscosity - thromboembolism

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