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Synthesis 2004(2): 205-207
DOI: 10.1055/s-2003-44381
DOI: 10.1055/s-2003-44381
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Cheap, Simple and Efficient Method for the Preparation of Symmetrical Carboxylic Acid Anhydrides
Further Information
Received
13 October 2003
Publication Date:
15 December 2003 (online)
Publication History
Publication Date:
15 December 2003 (online)
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Abstract
A manipulatively simple and facile one-pot procedure for the synthesis of symmetrical anhydride is reported. Treatment of carboxylic acids with tosyl chloride in K2CO3 media under solvent free conditions gives the corresponding anhydrides in good to excellent yields in a short reaction time via carboxylic sulfonic anhydride as the key intermediate.
Key words
anhydrides - tosyl chloride - grinding - carboxylic acid
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