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DOI: 10.1055/s-2003-44322
© Georg Thieme Verlag Stuttgart · New York
Alkoholgenuss und arterielle Hypertonie
Alcohol consumption and hypertensionPublikationsverlauf
eingereicht: 27.8.2003
akzeptiert: 31.10.2003
Publikationsdatum:
20. November 2003 (online)

Die arterielle Hypertonie ist ein wesentlicher Risikofaktor für atherosklerotische Gefäßveränderungen und kardiovaskuläre Ereignisse wie Myokardinfarkt und Schlaganfall [25]. Der regelmäßige Genuss alkoholischer Getränke ist mit einer Erhöhung des arteriellen Blutdruckes assoziiert [5] [20] [22]. Andererseits ist in zahlreichen Studien belegt, dass moderater Alkoholkonsum mit einer Senkung der Gesamtsterblichkeit und insbesondere kardiovaskulärer Ereignisse vergesellschaftet ist [6] [12] [15] [44-46] [54]. Es stellt sich somit die Frage, in welchen Situationen die potenziell günstigen Effekte eines mäßigen Alkoholkonsums keine negativen Folgen erwarten lassen, und wann Alkoholgenuss schädliche Auswirkungen hat. Im Folgenden sollen ein Überblick über die Zusammenhänge von Alkoholkonsum und arterieller Hypertonie vermittelt und unter Berücksichtigung der aktuellen Empfehlungen des „Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure” (JNC) praktische Hinweise für die individuelle Patientenführung und -beratung gegeben werden.
Literatur
- 1
Abe H, Kawano Y. et al .
Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive
patients.
Circulation.
1994;
89
2626-2633
Reference Ris Wihthout Link
- 2 Anstie F E. On the uses of wines in health and disease. JS Redfield, New York 1870: 11-13
Reference Ris Wihthout Link
- 3
Appel L J, Champagne C M, Harsha D W, Cooper L S, Obarzanek E, Elmer P J, Stevens V J, Vollmer W M, Lin P H, Svetkey L P, Stedman S W, Young D R. Writing Group of the PREMIER Collaborative Research Group .
Effects of comprehensive lifestyle modification on blood pressure control: main
results of the PREMIER clinical trial.
JAMA.
2003;
289
2083-2093
Reference Ris Wihthout Link
- 4
Arkwright P D, Beilin L J, Rouse I, Armstrong B K, Vandongen R.
Effects of alcohol use and other aspects of life-style on blood pressure levels
and prevalence of hypertension in a working population.
Circulation.
1982;
66
60-66
Reference Ris Wihthout Link
- 5
Beilin L J, Puddey I B.
Alcohol, hypertension and cardiovascular disease-implications for management.
Clin Exper Hyperten.
1993;
15
1157-1170
Reference Ris Wihthout Link
- 6
Böhm M, Rosenkranz S, Laufs U.
Das „French Paradox” - zu den potenziellen koronarprotektiven Wirkungen von
Alkohol, Wein und Weininhaltsstoffen.
Dtsch Med Wschr.
2002;
127
2748-2756
Reference Ris Wihthout Link
- 7
Burt V L, Whelton P, Roccella E J, Brown C, Cutler J A. et al .
Prevalence of hypertension in the US adult population. Results from the Third
National Health and Nutrition Examination Survey, 1988 - 1991.
Hypertension.
1995;
25
305-313
Reference Ris Wihthout Link
- 8 Carpenter W B. Influence of alcohol upon physical, chemical, and vital properties of the animal
tissue and fluids. Massachusetts Temperance Society, Boston In: Use and abuse of alcoholic liquors in health and disease 1861: 1-8
Reference Ris Wihthout Link
- 9
Chobanian A V, Bakris G L, Black H R, Cushman W C, Green L A, Izzo J L, Jones D W, Materson B J, Oparil S, Wright J T Jr, Roccella E J.
National Heart Lung and Blood Institute Joint National Committee on Prevention,
Detection, Evaluation, and Treatment of high blood pressure. National High Blood
Pressure Education Program Coordinating Committee. The seventh report of the
Joint National Committee on Prevention, Detection, Evaluation, and Treatment
of high blood pressure: The JNC 7 report.
JAMA.
2003;
289
2560-2572
Reference Ris Wihthout Link
- 10
Cook N R, Cohen J, Hebert P R, Taylor J O, Hennekens C H.
Implications of small reductions in diastolic blood pressure for primary prevention.
Arch Intern Med.
1995;
155
701-709
Reference Ris Wihthout Link
- 11
Curtis A B, James S A, Strongartz D S, Raghunathan T E, Harlow S.
Alcohol consumption and changes in blood pressure among African Americans: The
Pitt County Study.
Am J Epidemiol.
1997;
146
727-733
Reference Ris Wihthout Link
- 12
Di Castelnuovo A, Rotondo S, Iacoviello L, Donati M B, de Gaetano G.
Meta-analysis of wine and beer consumption in relation to vascular risk.
Circulation.
2002;
105
2836-2844
Reference Ris Wihthout Link
- 13
Dyer A R, Cutter G R, Liu K, Armstrong M A, Friedman G D, Hughes G H, Dolce J J, Raczynski J, Burke G, Manolio T.
Alcohol intake and blood pressure in young adults: The Cardia Study.
J Clin Epidemiol.
1990;
43
1-13
Reference Ris Wihthout Link
- 14
Elmer P J, Grimm R, Laing B, Grandits G, Svendsen K, Van Heel N, Betz E, Raines J, Link M, Stamler J, Neaton J.
Lifestile intervention: Results of the Treatment of Mild Hypertension Study
(TOMHS).
Prev Med.
1995;
24
378-388
Reference Ris Wihthout Link
- 15
Flesch M, Rosenkranz S, Erdmann E, Böhm M.
Alcohol and the risk of myocardial infarction.
Basic Res Cardiol.
2001;
96
128-135
Reference Ris Wihthout Link
- 16
Fuchs F D, Chambless L E, Whelton P K, Nieto F J, Heiss G.
Alcohol consumption and the incidence of hypertension. The Atherosclerosis Risk
in Communities (ARIC) Study.
Hypertension.
2001;
37
1242-1250
Reference Ris Wihthout Link
- 17
Gordon T, Kannel W B.
Drinking and ist relation to smoking, BP, blood lipids and uric acid.
Arch Intern Med.
1983;
143
1366-1374
Reference Ris Wihthout Link
- 18
He J, Bazzano L A.
Effects of lifestile modification on treatment and prevention of hypertension.
Curr Opin Nephrol Hypertens.
2000;
9
267-271
Reference Ris Wihthout Link
- 19
Kawano Y, Abe H, Kojima S, Ashida T.
Acute depressor effect of alcohol in patients with essential hypertension.
Hypertension.
1992;
20
219-226
Reference Ris Wihthout Link
- 20
Klatsky A L.
Alcohol and hypertension.
Clin Chim Acta.
1996;
246
91-105
Reference Ris Wihthout Link
- 21
Klatsky A L.
Is it the drink or the drinker? Circumstantial evidence only raises a probability.
Am J Clin Nutr.
1999;
69
2-3
Reference Ris Wihthout Link
- 22
Klatsky A L.
Alcohol and cardiovascular diseases. A historical overview.
Ann NY Acad Sci.
2002;
957
7-15
Reference Ris Wihthout Link
- 23
Klatsky A L, Friedman G D, Siegelaub A B. et al .
Alcohol consumption and blood pressure.
N Engl J Med.
1977;
296
1194-1200
Reference Ris Wihthout Link
- 24
Klatsky A L, Friedman G D, Armstrong M A.
The relationships of alcohol beverage use and other traits to blood pressur.
Circulation.
1986;
73
628-636
Reference Ris Wihthout Link
- 25
Lewington S, Clarke R, Qizilbash N. et al .
Age-specific relevance relevance of usual blood pressure to vascular mortality.
Lancet.
2002;
360
1903-1913
Reference Ris Wihthout Link
- 26
Lian C.
LŽalcoholisme cause dŽhypertension arterielle.
Bull Acad Med.
1915;
74
525-528
Reference Ris Wihthout Link
- 27
Maddrey W C.
Alcohol-induced liver disease.
Clin Liver Dis.
2000;
4
115-131
Reference Ris Wihthout Link
- 28
Maheswaran R, Gill J S, Davies P, Beevers D G.
High blood pressure due to alcohol. A rapidly reversible effect.
Hypertension.
1991;
17
787-792
Reference Ris Wihthout Link
- 29
Maier K P, Seitzer D, Haag G, Peskar B M, Gerok W.
Verlaufsformen alkoholischer Lebererkrankungen.
Klin Wochenschr.
1979;
57
311-317
Reference Ris Wihthout Link
- 30
Manolio T A, Levy D, Garrison R J. et al. .
Relation of alcohol intake to left ventricular mass: The Framingham Study.
J Am Coll Cardiol.
1991;
17
717-721
Reference Ris Wihthout Link
- 31
Marmot M G, Elliott P, Shipley M J, Dyer A R, Ueshima H, Beevers D G, Stamler R, Kesteloot H, Rose G, Stamler J.
Alcohol and blood pressure: the INTERSALT study.
BMJ.
1994;
308
1263-1267
Reference Ris Wihthout Link
- 32
Mayo-Smith M F.
Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based
practice guideline. American Society of Addiction Medicine Working Group on
Pharmacological Management of Alcohol Withdrawal.
JAMA.
1997;
278
144-151
Reference Ris Wihthout Link
- 33
Moreira L B, Fuchs F D, Moraes R S, Bredemeier M, Duncan B B.
Alcohol intake and blood pressure: The importance of the time elapsed since
last drink.
J Hypertens.
1998;
16
175-180
Reference Ris Wihthout Link
- 34
Mukamal K J, Maclure M, Muller J E. et al .
Prior alcohol consumption and mortality following acute myocardial infarction.
JAMA.
2001;
285
1965-1970
Reference Ris Wihthout Link
- 35
Muntwyler J, Hennekens C H, Buring J E. et al .
Mortality and light to moderate alcohol consumption after myocardial infarction.
Lancet.
1998;
352
1882-1885
Reference Ris Wihthout Link
- 36
Neal B, MacMahon S, Chapman N.
Effects of ACE-inhibitors, calcium antagonists, and other blood-pressure lowering
drugs.
Lancet.
2000;
356
1955-1964
Reference Ris Wihthout Link
- 37
Ogden L G, He J, Lydick E, Whelton P K.
Long-term absolute benefit of lowering blood pressure in hypertensive patients
according to the JNC VI risk stratification.
Hypertension.
2000;
35
539-543
Reference Ris Wihthout Link
- 38
Palmer A J, Fletcher A E, Bulpitt C J, Beevers D G, Coles E C, Ledingham J G, Petrie J C, Webster J, Dollery C T.
Alcohol intake and cardiovascular mortality in hypertensive patients: Report
from the Department of Health Hypertension Care Computing Project.
J Hypertens.
1995;
13
957-964
Reference Ris Wihthout Link
- 39
Puddey I B, Beilin L J, Vandongen R, Rouse I L, Rogers P.
Evidence for a direct effect of alcohol consumption on blood pressure in normotensive
men. A randomized controlled trial.
Hypertension.
1985;
7
707-713
Reference Ris Wihthout Link
- 40
Puddey I B, Beilin L J, Vandongen R.
Regular alcohol use raises blood pressure in treated hypertensive subjectsl.
Lancet.
1987;
I
647-651
Reference Ris Wihthout Link
- 41
Randin D, Vollenweider P, Tappy L, Jequier E. et al .
Suppression of alcohol-induced hypertension by dexamethasone.
N Engl J Med.
1995;
332
1733-1737
Reference Ris Wihthout Link
- 42
Renaud S C, Gueguen R, Siest G, Salamon R.
Wine, beer, and mortality in middle-aged men from eastern France.
Arch Intern Med.
1999;
159
1865-1870
Reference Ris Wihthout Link
- 43
Rosito G A, Fuchs F D, Duncan B B.
Dose-dependent biphasic effect of ethanol on 24-h blood pressure in normotensive
subjects.
Am J Hypertens.
1999;
12
236-240
Reference Ris Wihthout Link
- 44
Rimm E B, Giovannucci E L, Willett W C, Colditz G A, Ascherio A, Rosner B, Stampfer M J.
Prospective study of alcohol consumption and risk of coronary artery disease
in men.
Lancet.
1991;
338
464-468
Reference Ris Wihthout Link
- 45
Rimm E B, Klatsky A, Grobbee D, Stampfer M J.
Review of moderate alcohol consumption and reduced risk of coronary heart disease:
Is the effect due to beer, wine or spirits?.
BMJ.
1996;
312
731-736
Reference Ris Wihthout Link
- 46
Rosenkranz S, Knirel D, Dietrich H, Flesch M, Erdmann E, Böhm M.
Inhibition of the PDGF receptor by red wine flavonoids provides a molecular
explanation for the „French paradox”.
FASEB J.
2002;
16
1958-1960
Reference Ris Wihthout Link
- 47
Rupp H, Brilla C G, Maisch B.
Hypertonie und Alkohol: zentrale und periphere Mechanismen.
Herz.
1996;
21
258-264
Reference Ris Wihthout Link
- 48
Sano M, Wendt P E, Wirsen A, Stenberg G, Risberg J, Ingvar D H.
Acute effects of alcohol on regional cerebral blood flow in man.
J Stud Alcohol.
1993;
54
369-376
Reference Ris Wihthout Link
- 49
Sherif F M, Tarati A M, Ahmed S S, Sharif S I.
Basic aspects of GABA-transmission in alcoholism, with particular reference
to GABA-transaminase.
Eur Neuropsychopharmacol.
1997;
7
1-7
Reference Ris Wihthout Link
- 50
Stamler J, Caggiula A W, Grandits G A.
Relation of body mass and alcohol, nutrient, fiber, and caffeine intakes to
blood pressure in the special intervention and usual care groups in the Multiple
Risk Factor Intervention Trial.
Am J Clin Nutr.
1997;
65
(Suppl)
338S-365S
Reference Ris Wihthout Link
- 51
Stamler J, Liu K, Ruth K J, Pryer J, Greenland P.
Eight-year blood pressure change in middle-aged men. Relationship to multiple
nutrients.
Hypertension.
2002;
39
1000-1006
Reference Ris Wihthout Link
- 52
Takashima Y, Kokaze A, Matsunaga N, Yoshida M, Sekiguchi K, Sekine Y, Sumiya Y.
Relations of blood pressure to angiotensinogen gene T174M polymorphism and alcohol
intake.
J Physiol Anthropol Appl Human Sci.
2003;
22
187-194
Reference Ris Wihthout Link
- 53
Teli M R, Day C P, Burt A D, Bennett M K, James O FW.
Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty
liver.
Lancet.
1995;
346
987-990
Reference Ris Wihthout Link
- 54
Thun M J, Peto R, Lopez A D. et al .
Alcohol consumption and mortality among middle-aged and elderly US adults.
N Engl J Med.
1997;
337
1705-1714
Reference Ris Wihthout Link
- 55
WHO - International Society of Hypertension .
1999 Guidelines for the management of hypertension.
Clin Exper Hypertension.
1999;
21
1009-1060
Reference Ris Wihthout Link
- 56
Xin X, He J, Frontini M G, Ogden L G, Motsamai O I, Whelton P K.
Effects of alcohol reduction on blood pressure.
Hypertension.
2001;
38
1112-1117
Reference Ris Wihthout Link
Dr. med. Stephan Rosenkranz
Klinik III für Innere Medizin, Universität zu Köln
Joseph-Stelzmann-Straße 9
50924 Köln (Lindenthal)
Telefon: 0221/4785159
Fax: 0221/4786490
eMail: stephan.rosenkranz@medizin.uni-koeln.de
