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DOI: 10.1055/s-2003-43259
Georg Thieme Verlag Stuttgart · New York
Correlation of Corpus Callosal Morphometry with Cognitive and Motor Function in Periventricular Leukomalacia
Publication History
Received: January 3, 2003
Accepted after Revision: June 5, 2003
Publication Date:
04 November 2003 (online)
![](https://www.thieme-connect.de/media/neuropediatrics/200305/lookinside/thumbnails/10.1055-s-2003-43259-1.jpg)
Abstract
Purpose
We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL).
Methods
Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T1-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise t-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment.
Results
29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment.
Conclusion
Global and regional corpus callosal morphology can be quantified using deformation functions.
Key words
Corpus callosum - morphometry - cognitive function - motorfunction - periventricular leukomalacia - cerebral palsy
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M. D. Elias R. Melhem
Department of Radiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
USA
Email: emelhem@rad.jhu.edu