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Planta Med 2003; 69(9): 864-866
DOI: 10.1055/s-2003-43204
Letter
© Georg Thieme Verlag Stuttgart · New York

A Novel Cytotoxic Guttiferone Analogue from Garcinia macrophylla from the Suriname Rainforest

Russell B. Williams1 , Jeannine Hoch1 , Thomas E. Glass1 , Randy Evans2 , James S. Miller2 , Jan H. Wisse3 , David G. I. Kingston1
  • 1Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
  • 2Missouri Botanical Garden, St. Louis, Missouri, USA
  • 3Bedrijf Geneesmiddelen Voorziening Suriname, Geyersvlijit, Suriname
Funding: We gratefully acknowledge the Fogarty Center, National Institutes of Health, for supporting this work with International Cooperative Biodiversity Grant Number U01 TW/CA-00313History: Biodiversity Conservation and Drug Discovery in Suriname, Part 14. For Part 13, see Ref. 1
Further Information

Publication History

Received: January 28, 2003

Accepted: May 10, 2003

Publication Date:
04 November 2003 (online)

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A Novel Cytotoxic Guttiferone Analogue from Garcinia macrophylla from the Suriname RainforestPlanta Med 2005; 71(04): 354-354
DOI: 10.1055/s-2005-864129

Abstract

Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC50 values of 6.8 and 8.0 μg/mL, respectively.

References

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Dr. David G. I. Kingston

Department of Chemistry, M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

Virginia 24061

USA

Phone: +1-540-231-6570

Fax: +1-540-231-7702

Email: dkingston@vt.edu

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