The First Direct Chlorination of Iodoarenes - A Side-chain Directed Process

Abstract

The chlorination of electron rich iodoarenes with MoCl₅ proceeds with methoxycarbonylmethyl as the directing group. The transformation is selective and without loss of the valuable iodo substituent.

Key words

molybdenum - protective groups - iodoarenes - chlorination - radical reactions.

References

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13

All isomeric products could not be separated on a preparative scale. NMR spectra of the mixture clearly identified the chlorinated compounds and further characterization was successfully performed by GC-MS methods.

17

Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication CCDC 211377. Copies of the data can be obtained free of charge on application to The Director CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: [phone], e-mail: [e-mail]].