Synlett 2003(12): 1886-1888  
DOI: 10.1055/s-2003-41473
LETTER
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of the Angucylinone Antibiotic (+)-Rubiginone B2 [1]

Aris Kalogerakis, Ulrich Groth*
Fachbereich Chemie, Universität Konstanz, Fach M-720, Universitätsstraße 10, 78457 Konstanz, Germany
Fax: +49(7531)884155; e-Mail: ulrich.groth@uni-konstanz.de;
Further Information

Publication History

Received 30 June 2003
Publication Date:
19 September 2003 (online)

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Abstract

A new chiral synthesis of (+)-rubiginone B2 is reported. The intramolecular cobalt-mediated [2+2+2]-cycloaddition of a triyne precursor, synthesized from (+)-citronellal, afforded a chiral anthracene, which led after a two-step oxidation to the angucycli­none antibiotic.