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Synlett 2003(12): 1841-1843
DOI: 10.1055/s-2003-41408
DOI: 10.1055/s-2003-41408
LETTER
© Georg Thieme Verlag Stuttgart · New York
Highly Convenient, One-Pot Synthesis of Nitriles from Aldehydes Using the NH2OH·HCl/NaI/MeCN System
Weitere Informationen
Received
25 July 2003
Publikationsdatum:
28. August 2003 (online)
Publikationsverlauf
Publikationsdatum:
28. August 2003 (online)
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Abstract
Direct transformation of both aliphatic and aromatic aldehydes to the corresponding nitriles, can be easily performed by the reaction of an aldehyde with a slight excess of hydroxylamine hydrochloride, in refluxing acetonitrile and in the presence of 0.5 equivalents of sodium iodide as catalyst.
Key words
aldehydes - hydroxylamine hydrochloride - sodium iodide - catalysis - nitriles
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