Cardiovascular risk factors in womenV. Stangl1
, G. Baumann1
, K. Stangl1
1Med. Klinik mit Schwerpunkt Kardiologie,
Angiologie, Pneumologie (Direktor: Prof. Dr. med. Gert Baumann), Charité
der Humboldt-Universität, Campus Mitte
Wir wissen heute, dass es eine Reihe geschlechtsspezifischer
Unterschiede hinsichtlich Entstehung, Klinik, Verlauf und Prognose der
koronaren Herzkrankheit (KHK) gibt [2]. Bei Frauen
entwickelt sich die KHK circa 10 - 15 Jahre später als
beim Mann, das Risiko steigt - vermutlich durch Wegfall der endogenen
Steroidhormone - nach der Menopause an. Von besonderer Bedeutung ist die
Tatsache, dass bei Frauen in der Regel zwar die gleichen Faktoren wie bei
Männern atherogen wirken, diese aber in ihrer Wertigkeit zum Teil stark
differieren: So ist bei Frauen der Diabetes mellitus mit einem zwei- bis
dreifach höheren koronaren Risiko als bei Männern assoziiert. Eine
bessere Kenntnis der Unterschiede in der atherogenen Potenz der Risikofaktoren
ist somit für eine optimale geschlechtsspezifische Prävention und
Therapie entscheidend [51]. Hier sollen die
frauenspezifischen Besonderheiten im koronaren Risikofaktorprofil aufgezeigt,
analysiert und in ihrer Wertigkeit dargestellt werden.
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