Synthesis 2003(15): 2325-2330  
DOI: 10.1055/s-2003-41072
PAPER
© Georg Thieme Verlag Stuttgart · New York

Facile Baylis-Hillman Reaction of Substituted 3-Isoxazolecarbaldehydes: The Impact of a Proximal Heteroatom Within a Heterocycle on the Acceleration of the Reaction [1]

Amrendra K. Roy, Sanjay Batra*
Medicinal Chemistry Division, Central Drug Research Institute, PO Box 173, Lucknow-226001, India
Fax: +91(522)2223405; e-Mail: batra_san@yahoo.co.uk;
Further Information

Publication History

Received 4 July 2003
Publication Date:
23 September 2003 (online)

Abstract

The fast and facile Baylis-Hillman reaction in substituted 3-isoxazolecarbaldehydes confirms the impact of the proximal heteroatom within a heterocycle towards enhanced reactivity of the formyl group for this reaction.

1

CDRI Communication No. 6430.

1

CDRI Communication No. 6430.