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Synthesis 2003(13): 2011-2014
DOI: 10.1055/s-2003-41022
DOI: 10.1055/s-2003-41022
PAPER
© Georg Thieme Verlag Stuttgart · New York
Concise Synthesis of Coscinamide B, a Bisindolic Enamide from Marine Sponge
Further Information
Received
22 April 2003
Publication Date:
19 August 2003 (online)
Publication History
Publication Date:
19 August 2003 (online)
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Abstract
An efficient, four-step synthesis of coscinamide B (2) from tryptamine is reported, in which a one-pot benzylic bromination and subsequent in situ dehydrobromination in the absence of an added base is the key step.
Key words
coscinamide B - bisindolic enamide - synthesis - tryptamine - in situ dehydrobromination
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