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Synthesis 2003(11): 1667-1670
DOI: 10.1055/s-2003-40883
DOI: 10.1055/s-2003-40883
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York
Synthesis of Chiral Analogues of FTY720 and its Phosphate
Further Information
Received
16 May 2003
Publication Date:
25 July 2003 (online)
Publication History
Publication Date:
25 July 2003 (online)
Abstract
Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucidate FTY720’s novel mechanism of action.
Key words
phosphates - sphingolipids - stereoselective synthesis - drugs - chiral auxiliaries
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References
These authors contributed equally to this study.
9Commercially available as OMe-ethers from Merck and Fluka.