Onkolytische Viren als innovativer Ansatz in der Therapie gastrointestinaler Tumoren

Zusammenfassung

Für die gastroenterologische Onkologie werden zusätzliche Therapiestrategien benötigt, die auf neuartigen Mechanismen basieren und keine Kreuzresistenz hinsichtlich gegenwärtiger Standardtherapien zeigen. Einen dieser Ansätze stellt die Virotherapie dar, bei der replikationskompetente virale Vektoren mit stark ausgeprägter onkolytischer Funktion zum Einsatz kommen und gegenwärtig innerhalb präklinischer und klinischer Studien evaluiert werden. Unter Einsatz der Methodik der molekularen Virologie ist eine Fortentwicklung der momentan verfügbaren Vektorsysteme insbesondere zur Verbesserung der onkolytischen Aktivität, der Tumorselektivität, der Durchwanderungsfähigkeit von Tumoren sowie der Sicherheitsaspekte erforderlich.

Abstract

Gastroenterological oncology requires new strategies with new mechanisms of action and without cross-resistance to currently available treatment regimes. Virotherapy which is based on the employment of replication-competent viral vectors exhibiting strong oncolytic properties is such an approach currently under preclinical/clinical investigation. Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety.

Schlüsselwörter

Virotherapie - Onkolyse - Tumorgentherapie - vermehrungsfähige virale Vektoren

Key words

Virotherapy - oncolysis - cancer gene therapy - replication-competent viral vectors

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