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Synthesis 2003(9): 1433-1440
DOI: 10.1055/s-2003-40196
DOI: 10.1055/s-2003-40196
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart ˙ New York
Multicomponent Synthesis of Highly Substituted Imidazolines via a Silicon Mediated 1,3-Dipolar Cycloaddition
Further Information
Publication History
Publication Date:
24 June 2003 (online)
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Abstract
A diastereoselective multicomponent synthesis of highly functionalized imidazolines is reported. A silicon mediated 1,3 dipolar cycloaddition of the in situ generated münchnone with an imine resulted in the formation of highly substituted imidazolines. The imidazolines contain a four-point diversity and two stereocenters and the cycloaddition reaction is applicable to aryl, alkyl, acyl, and heterocyclic substitutions.
Key words
imidazolines - 1,3-dipolar cycloaddition - diastereoselective - heterocycles - imidazoles
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