Liquorfiltration als experimentelle Therapie bei therapieresistenten Psychosen Borna-Disease-Virus-seropositiver Patienten

Zusammenfassung

Eine milde Borna-Disease-Virus-Enzephalitis mag einer Subgruppe affektiver oder schizophrener Spektrumpsychosen zugrunde liegen. Deshalb haben wir vier BDV-seropositive Patienten mit therapieresistenten schizophrenen oder affektiven Psychosen in einer experimentellen Add-on-Therapie mit Liquorfiltration (CSFF) behandelt. CSFF stellt eine effektive immunmodulatorische Therapie bei Guillain-Barré-Syndrom, einer autoimmuninflammatorischen neurologischen Erkrankung, dar. CSFF erscheint nach diesen ersten Ergebnissen auch bei therapieresistenten Psychosen effektiv zu sein.

Abstract

According to previous investigations, mild Borna disease virus encephalitis may underlie a subgroup of affective or schizophrenic type psychoses. And virus-induced immune pathology may underlie even a larger subgroup of psychoses. We treated BDV seropositive patients suffering from therapy resistant schizophrenic or affective spectrum psychoses by cerebrospinal fluid filtration (CSFF) in an experimental add-on treatment. CSFF was shown previously to be an effective immune modulatory treatment in autoimmune neurological disease, Guillain-Barré syndrome. CSFF appears to be an effective treatment in therapy resistant psychosis also, but only 4 patients were treated yet.

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