Liquorfiltration als experimentelle Therapie bei therapieresistenten Psychosen Borna-Disease-Virus-seropositiver Patienten
Therapeutische Effekte, BefundeCSF Filtration as Experimental Therapy in Therapyresistant Psychoses in Borna Disease Virus-Seropositive PatientsTherapeutic Effects, FindingsKarl Bechter1
, Volkhard Schreiner1
, Sibylle Herzog3
, Norbert Breitinger2
, Kurt H. Wollinsky5
, Heinrich Brinkmeier4
, Peter Aulkemeyer4
, Frank Weber4
, Reinhold Schüttler1
1Abteilung Psychiatrie II der Universität Ulm, Bezirkskrankenhaus Günzburg
2Abteilung Neurologie und Neurologische Rehabilitation, Bezirkskrankenhaus Günzburg
3Institut für Virologie, Justus-Liebig-Universität Gießen
4Abteilung Allgemeine Physiologie der Universität Ulm
5Abteilung Anästhesiologie und Intensivmedizin, RKU Ulm
Diese Forschungen wurden unterstützt durch die Theodore and Vada Stanley-Foundation, Bethesda/USA
Eine milde Borna-Disease-Virus-Enzephalitis mag einer Subgruppe affektiver oder schizophrener Spektrumpsychosen zugrunde liegen. Deshalb haben wir vier BDV-seropositive Patienten mit therapieresistenten schizophrenen oder affektiven Psychosen in einer experimentellen Add-on-Therapie mit Liquorfiltration (CSFF) behandelt. CSFF stellt eine effektive immunmodulatorische Therapie bei Guillain-Barré-Syndrom, einer autoimmuninflammatorischen neurologischen Erkrankung, dar. CSFF erscheint nach diesen ersten Ergebnissen auch bei therapieresistenten Psychosen effektiv zu sein.
Abstract
According to previous investigations, mild Borna disease virus encephalitis may underlie a subgroup of affective or schizophrenic type psychoses. And virus-induced immune pathology may underlie even a larger subgroup of psychoses. We treated BDV seropositive patients suffering from therapy resistant schizophrenic or affective spectrum psychoses by cerebrospinal fluid filtration (CSFF) in an experimental add-on treatment. CSFF was shown previously to be an effective immune modulatory treatment in autoimmune neurological disease, Guillain-Barré syndrome. CSFF appears to be an effective treatment in therapy resistant psychosis also, but only 4 patients were treated yet.
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