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Synthesis 2003(8): 1241-1247
DOI: 10.1055/s-2003-39397
DOI: 10.1055/s-2003-39397
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York
Yb(OTf)3-Catalyzed One-Pot Synthesis of Quinazolin-4(3H)-ones from Anthranilic Acid, Amines and Ortho Esters (or Formic Acid) in Solvent-Free Conditions
Weitere Informationen
Received
20 November 2002
Publikationsdatum:
26. Mai 2003 (online)
Publikationsverlauf
Publikationsdatum:
26. Mai 2003 (online)
![](https://www.thieme-connect.de/media/synthesis/200308/lookinside/thumbnails/10.1055-s-2003-39397-1.jpg)
Abstract
An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)3 in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.
Key words
quinazolin-4(3H)-ones - ytterbium triflate - one-pot reaction - anthranilic acid - amine
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