Planta Med 2003; 69(4): 356-360
DOI: 10.1055/s-2003-38872
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Eremophilenolides and Other Constituents from the Roots of Ligularia sagitta

Xu-Qin Li1 , Kun Gao1 , Zhong-Jian Jia1
  • 1College of Chemistry and Chemical Engineering, National Laboratory of Applied Organic Chemistry, Lanzhou University, People’s Republic of China
Further Information

Publication History

Received: August 19, 2002

Accepted: November 23, 2002

Publication Date:
23 April 2003 (online)

Abstract

Chemical investigation of the roots of Ligularia sagitta has resulted in the characterization of six eremophilenolides 6β,8β-dimethoxy-10β-hydroxyeremophil-7(11)-en-12,8α-olide (1), 6β-angeloyloxy-10β-hydroxy-8β-methoxyeremophil-7(11)-en-12,8α-olide (2), 6β-(2′-methylbutanoyloxy)-10β-hydroxy-8β-methoxyeremophil-7(11)-en-12,8α-olide (3), 6β-angeloyloxy-10β-hydroxy-8α-methoxyeremophil-7(11)-en-12,8β-olide (4), 6β-(2′-methylbutanoyloxy)-10β-hydroxy-8α-methoxyeremophil-7(11)-en-12,8β-olide (5) and 8β,10β-dihydroxy-6β-methoxyeremophil-7(11)-en-12,8α-olide (6), together with one monoterpene (3R,4R,6S)-3,6-dihydroxy-1-menthene (7), two triterpenes lupeol (8) and ursolic acid (9), and β-sitosterol (10). The structures of five new constituents (1 - 5) were elucidated by spectroscopic methods including 2D-NMR experiments. The compounds 1, 5 and 7 showed antibacterial activity by being assayed against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

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Prof. Dr. Zhong-Jian Jia and Dr. Kun Gao

College of Chemistry and Chemical Engineering

National Laboratory of Applied Organic Chemistry

Lanzhou University

Lanzhou 730000

People’s Republic of China

Fax: +86-0931-8912582

Email: jiazj@lzu.edu.cn