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Synlett 2003(6): 0864-0866
DOI: 10.1055/s-2003-38735
DOI: 10.1055/s-2003-38735
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York
Polystyrene Resins Containing 1,3-Propanedithiol Functions for Solid-Phase Organic Syntheses
Further Information
Received
23 December 2002
Publication Date:
17 April 2003 (online)
Publication History
Publication Date:
17 April 2003 (online)
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Abstract
A completely odourless reliable synthesis of styrenic resins containing 1,3-propanedithiol functions able to form 1,3-dithiane derivatives with carbonyl compounds and back up the chemistry of thioacetals and thioketals is reported. The degree of functionalisation of the resin can be easily determined through the composition of the copolymerising mixture and confirmed by titration. The resins show good accessibility to various reagents and are effective for solid-phase synthesis being exploitable in the field of combinatorial chemistry.
Key words
solid-phase synthesis - polymeric dithiols - polymeric dithianes - umpolung reactions - ketones
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