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DOI: 10.1055/s-2003-38387
Dinucleotide Polymorphisms Present in the 5’-Flanking Region of the Human H2 Relaxin Gene, but not in the Corresponding Region of the H1 Gene
Publication History
Received 4 March 2002
Accepted after revision 30 July 2002
Publication Date:
01 April 2003 (online)
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Abstract
Relaxin is a peptide hormone that, in humans, is encoded by two genes referred to as H1 and H2, both located into chromosome 9p24.1. We have searched for polymorphisms in the 5’-flanking sequence of these genes. Both genes possess a CT repeat followed by a GT repeat. CT and GT repeats of the H2 gene are longer than those of the H1 gene. Moreover, CT and GT repeats of the H2 gene, but not those of the H1 gene, show length polymorphism. Protein-DNA interaction experiments suggest that difference between the H1 and H2 GT repeats may have arisen because the requirements of the transcriptional regulation of the two genes are different.
Key words
Polymorphisms - Microsatellites - Relaxin - Protein-DNA Interaction
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Prof. G. Damante
Dipartimento di Scienze e Tecnologie Biomediche
Piazzale Kolbe 1 · 33100 Udine · Italy
Phone: + 39 (432) 49 43 74
Fax: + 39 (432) 49 43 79
Email: GDamante@makek.dstb.uniud.it