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Am J Perinatol 2003; 20(2): 091-096
DOI: 10.1055/s-2003-38343
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4693

Successful Use of Tissue Plasminogen Activator in Catheter-Related Intracardiac Thrombus of a Premature Infant

M. J. Torres-Valdivieso1 , J. Cobas1 , C. Barrio1 , C. Muñoz1 , M. Pascual1 , C. Orbea1 , E. Rodriguez1 , F. Gutiérrez2
  • 1Section of Perinatology, Hospital 12 de Octubre, Madrid, Spain
  • 2Section of Pediatric Cardiology, Hospital 12 de Octubre, Madrid, Spain
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Publication History

Publication Date:
27 March 2003 (online)

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ABSTRACT

The incidence of clinically apparent neonatal thrombosis is about 0.1 to 0.2% in the neonatal intensive care unit (NICU). The optimal treatment modalities for neonates with thromboses are not known. We report on our experience with recombinant tissue type plasminogen activator (rt-PA) in a premature infant with an intracardiac thrombus.

KEYWORDS

rt-PA - newborn - thrombosis

REFERENCES

  • 1 Lumb P D. Complications of central venous catheters.  Crit Care Med . 1993;  21 1105-1106
    PubMedGoogle Scholar
  • 2 Schmidt B, Zipensky A. Thrombotic disease in newborn infants.  Clin Perinatol . 1984;  11 461-488
    PubMedGoogle Scholar
  • 3 Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and International Registry.  Pediatrics . 1995;  96 939-943
    PubMedGoogle Scholar
  • 4 Edstrom C, Christensen R. Evaluation and treatment of thrombosis in the neonatal intensive care unit.  Clin Perinatol . 2000;  27 623-641
    PubMedGoogle Scholar
  • 5 Monagle P, Adams M, Mahoney M. et al . Outcome of pediatric thromboembolic disease: a report from the Canadian childhood thrombophilia registry.  Pediatr Res . 2000;  47 763-766
    CrossrefPubMedGoogle Scholar
  • 6 Giuffre B, Compagnoni G, Farina C, Mosca F. Succesful use of tissue plasminogen activator (t-PA) in catheter-related intracardiac thrombi of the premature infants.  Acta Paediatr . 1998;  87 695-698
    CrossrefPubMedGoogle Scholar
  • 7 Van Overmeire B, Van Reempts J P, Van Acker J K. Intracardiac thrombus formation with rapidly progressive heart failure in the neonate: treatment with tissue type plasminogen activator.  Arch Dis Child . 1992;  67 443-444
    PubMedGoogle Scholar
  • 8 Alkalay A, Mazkereth R, Santulli T, Pomerance J. Central venous line thrombosis in premature infants: a case management and literature review.  Am J Perinatol . 1993;  10 323-326
    PubMedGoogle Scholar
  • 9 De Schepper J, Hachimi-Idrissi S, Cham B. et al . Diagnosis and management of catheter-related infected intracardiac thrombosis in premature infants.  Am J Perinat . 1993;  10 39-42
    PubMedGoogle Scholar
  • 10 Schmidt B, Andrew M. Report of scientif and standardization subcommittee on neonatal hemostasis. Diagnosis and treatment of neonatal thrombosis.  Thromb Haemost . 1992;  67 381-382
    PubMedGoogle Scholar
  • 11 Streif W, Mitchell L, Andrew M. Antithrombotic therapy in children.  Curr Opin Pediatr . 1999;  11 56-64
    CrossrefPubMedGoogle Scholar
  • 12 Nowak-Göttl U, Auberger K, Halimeh S. et al . Thrombolysis in newborns and infants.  Thromb Haemost . 1999;  82 (suppl 1) 112-116
    PubMedGoogle Scholar
  • 13 Farnoux C, Camard O, Pinquer D. et al . Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates.  J Pediatr . 1998;  133 137-140
    CrossrefPubMedGoogle Scholar
  • 14 Weiner G, Castle V, DiPietro M, Faix R. Successful treatment of neonatal arterial thromboses with recombinant tissue plasminogen activator.  J Pediatr . 1998;  133 133-136
    CrossrefPubMedGoogle Scholar
  • 15 Weinschenk N, Pelidis M, Fiascone J. Combination thrombolytic and anticoagulant therapy for bilateral renal vein thrombosis in a premature infant.  Am J Perinatol . 2001;  18 293-298
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Anderson B J, Keeley S R, Johnson N D. Caval thrombolysis in neonates using low doses of recombinant human tissue-type plasminogen activator.  Anaesth Intensive Care . 1991;  19 22-27
    PubMedGoogle Scholar
  • 17 Dillon P W, Fox P S, Berg C J, Cardella J F. et al . Recombinant tissue plasminogen activator for neonatal and pediatric vascular thrombolytic therapy.  J Pediatr Surg . 1993;  28 1264-1269
    PubMedGoogle Scholar
  • 18 Hartmann J, Hussein A, Trowitzsch E. Treatment of neonatal thrombus formation with recombinant tissue plasminogen activator : six years experience and review of the literature.  Arch Dis Child Fetal Neonatal Ed . 2001;  85 F8-F22
    PubMedGoogle Scholar
  • 19 Ferrari F, Vagnarelli F, Gargano G. et al . Early intracardiac thrombosis in preterm infants and thrombolysis with recombinant tissue type plasminogen activator.  Arch Dis Child Fetal Neonatal Ed . 2001;  85 F66-F69
    CrossrefPubMedGoogle Scholar
  • 20 Zenz W, Muntean W. Thrombolytic therapy in children: an update.  Fibrinolysis . 1995;  9(suppl) 33-36
    CrossrefPubMedGoogle Scholar
  • 21 Kennedy L A, Drummond W H, Knight M E. et al . Successful treatment of neonatal aortic thrombosis with tissue plasminogen activator.  J Pediatr . 1990;  116 798-801
    PubMedGoogle Scholar
  • 22 Levy M, Benson L N, Burrows P E. et al . Tissue plasminogen activator for the treatment of thromboembolism in infants and children.  J Pediatr . 1991;  118 467-472
    CrossrefPubMedGoogle Scholar
  • 23 Deeg K H, Wolfel D, Rupprecht T. Diagnosis of neonatal aortic thrombosis by colour coded Doppler sonography.  Pediatr Radiol . 1992;  22 62-63
    PubMedGoogle Scholar