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DOI: 10.1055/s-2003-37707
© Georg Thieme Verlag Stuttgart · New York
Honokiol Ameliorates Cerebral Infarction from Ischemia-Reperfusion Injury in Rats
Publikationsverlauf
Received: June 17, 2002
Accepted: September 22, 2002
Publikationsdatum:
07. März 2003 (online)
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Abstract
Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and an anti-platelet agent in biological systems with an anti-arrhythmic effect and a myocardial protective effect on ischemia-reperfusion injury. We examined the neuroprotective effect of honokiol in rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle cerebral artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed (treatment groups). The results showed that there was no significant hemodynamic change after intravenous infusion of honokiol at the dosages of 10 - 8, 10 - 7 and 10 - 6 g/kg in both groups. However, honokiol significantly reduced the total volume of infarction at the doses of 10 - 7 or 10 - 6 g/kg in both pretreatment and treatment groups. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. This beneficial effect may be related to its antioxidant effect and anti-platelet aggregation activity.
Key words
Honokiol - antioxidant - free radical - ischemia - reperfusion - cerebral infarction - Magnolia officinalis - Magnoliaceae
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Professor Shen-Kou Tsai
National Taiwan University and National Yang-Ming University and Taipei Veterans General Hospital
201 Shih-Pai Road, Section 2
Taipei
Taiwan
Republic of China
eMail: sktsai@vghtpe.gov.tw
Fax: + 886-2-28 751 597