Download PDF
J Reconstr Microsurg 2003; 19(1): 017-020
DOI: 10.1055/s-2003-37186
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1 (212) 584-4662

Nerve Anastomosis with Glue: Comparative Histologic Study of Fibrin and Cyanoacrylate Glue

K. Wieken1 , K. Angioi-Duprez2 , A. Lim3 , L. Marchal4 , M. Merle1
  • 1European Hand Institute, Maxéville-Nancy, France
  • 2Laboratoire d'Anatomie pathologique, Faculté de Médecine de Nancy, Vandoeuvre, France
  • 3National University Hospital, Singapore
  • 4Laboratoire de Microscopie Electronique, Faculté de Médecine de Nancy, Vandoeuvre, France
Further Information

Publication History

Publication Date:
12 February 2003 (online)

Also available at
    Permissions and Reprints

ABSTRACT

The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.

KEYWORD

Nerve repair - cyanocrylate - glue - fibrin

REFERENCES

  • 1 Egloff D V, Narakas A. Anastomoses nerveuses par fibrino-collage.  Ann Chir Main . 1983;  2 101-115
    CrossrefPubMedGoogle Scholar
  • 2 Gilbert A. Colle biologique: arguments expérimentaux et cliniques.  Ann Chir Main . 1989;  8 300-301
    PubMedGoogle Scholar
  • 3 Lehmann R AW, Hayes G J, Leonard F. Toxicity of alkyl 2-cyanoacrylates.  Arch Surg . 1966;  93 441-446
    PubMedGoogle Scholar
  • 4 Tseng Y-C, Hyon S-H, Ikada Y. In vivo evaluation of 2-cyanoacrylates as surgical adhesives.  J Appl Biomaterials . 1990;  1 11-19
    PubMedGoogle Scholar
  • 5 Montanaro I, Arciola C R, Cenni E. Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use.  Biomaterials . 2001;  22 59-66
    CrossrefPubMedGoogle Scholar
  • 6 De Mecinaceli L. Coating the stumps without strain in cell surgery to repair divided nerves.  In: De Mecinaceli L, ed. Paris: CASIS-CID 1994: 233-244
    Google Scholar
  • 7 Menovsky T. Modified surgical approach of the rat sciatic nerve.  Microsurgery. 1995;  16 510-511
    PubMedGoogle Scholar