Synlett 2003(2): 0215-0218
DOI: 10.1055/s-2003-36801
LETTER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of syn- and anti-3,5-Dihydroxy-6-heptenoates from 2-Deoxy-d-ribose: Intermediates for Polyols Synthesis

Peter Zakrzewski, Cheuk K. Lau*
Medicinal Chemistry Department, Merck Frosst Centre For Therapeutic Research, 16711 Trans Canada Hwy., Kirkland, Québec, H9H 3L1, Canada
Fax: +1(514)4284900; e-Mail: lau@merck.com;
Further Information

Publication History

Received 10 December 2002
Publication Date:
22 January 2003 (online)

Abstract

Syntheses of all four diastereomers of syn- and anti-3,5-dihydroxy-6-heptenoate, proven versatile synthetic intermediates that are enantiomerically pure and functionally differentiated at both ends, have been developed.