Abstract
3-Hydroxythiophenol is a versatile intermediate for the synthesis
of medicinal and heterocyclic compounds. Two novel and practical
syntheses of 3-hydroxythiophenol are achieved using readily available
and inexpensive starting materials. An overall cost comparison of
these syntheses is also given.
Key words
3-hydroxythiophenol - Grignard reactions - diazo
compounds - sulfur - practical synthesis
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address: Department of Chemistry, Bayer Research Center, Pharmaceutical Division,
400 Morgan Lane, West Haven, CT 06516. E-mail: mingbao.zhang.b@bayer.com;
telephone +1(203)8125906; fax +1(203)8163505
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