Semin Musculoskelet Radiol 2002; 06(4): 341-346
DOI: 10.1055/s-2002-36733
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Metabolic Disease in Animals

Si-kwang Liu
  • Department of Pathology, The Animal Medical Center; Weill Medical College of Cornell University; and Wildlife Conservation Society, New York, New York
Further Information

Publication History

Publication Date:
22 January 2003 (online)

ABSTRACT

Rickets is a metabolic bone disorder characterized by osteopenic changes resulting from the failure of calcification of the osteoid matrix and absent mineralization of hypertrophic cartilage cells at the epiphyseal growth plates in growing primates, herbivores, swine, carnivores, and birds. The causes of rickets include inadequate dietary provision of calcium, phosphorus, and vitamin D. Osteomalacia in reptiles, simian bone disease in nonhuman primates, and osteodystrophia fibrosa (secondary hyperparathyroidism) or "bran disease" in herbivores are caused by a diet that has a much higher content of phosphorus than calcium, combined with inadequate exposure to direct sunlight. Medullary bone consists of interconnected spicules of bone resembling embryonic bone and is established in relation to the shell formation cycle of laying birds. Hypertrophic osteodystrophy develops in large-breed growing dogs, chickens, and guinea pigs and is possibly caused by vitamin C deficiency. Tibial dyschondroplasia is a defect in endochondral ossification characterized by a widened proximal tibial physis that is not penetrated by metaphyseal vascular sprouts, commonly found in growing broiler chickens, turkeys, and exotic birds.

REFERENCES

  • 1 Liu S K. Rickets in a 6-month-old monkey.  Skeletal Radiol . 1996;  25 70-72
  • 2 Liu S K, Shyu J J, Chu R. A Color Atlas of Bone Pathology. Taipei, Taiwan: Pig Research Institute Taiwan 2001
  • 3 Stern P H. The D vitamin and bone.  Pharmacol Rev . 1980;  32 47-58
  • 4 Krook L, Barrell R B. Simian bone disease. A secondary hyperparathyroidism.  Cornell Vet . 1962;  52 459-491
  • 5 Pepper T A, Bennett D, Brown P J, Taylor D J. Rickets in growing pigs and response to treatment.  Vet Rec . 1978;  103 4-12
  • 6 Johnson K A, Church D B, Barton R J, Wood K W. Vitamin D deficient rickets in a Saint Bernard dog.  J Small Anim Pract . 1988;  29 657-666
  • 7 Lacey D L, Huffer W E. Studies on the pathogenesis of avian rickets. I. Changes in epiphyseal and metaphyseal vessels in hypocalcemic and hypophosphatemic rickets.  Am J Pathol . 1982;  109 288-301
  • 8 Huffer W E, Lacey D L. Studies on the pathogenesis of avian rickets. II. Necrosis of perforating epiphyseal vessels during recovery from rickets in chickens caused by vitamin D3 deficiency.  Am J Pathol . 1982;  109 302-309
  • 9 Mankin H J. Rickets, osteomalacia, and renal osteodystrophy.  J Bone Joint Surg . 1974;  56A 101-128
  • 10 Simon W H, Garman R A. Simian bone disease: unrecognized rickets in Rhesus monkeys.  Clin Orthop . 1970;  73 232-240
  • 11 Lesbanijines G, Drieux H. Osteodystrophic fibreuse du pore, de la chevre.  Rec Med Vet . 1949;  127 579-592
  • 12 Ushijima J. Biochemical studies on so-called osteomalacia (osteodystrophic fibrosa) in horses.  Jap J Vet Res . 1958;  6 1-18
  • 13 Jubb K VF, Kennedy P C. Pathology of Domestic Animals.  New York: Academic Press 1963
  • 14 Liu S k, Moroff S. Synovial sarcoma, epithelial hyperplasia in humoral air sacs, and formation of medullary bone in a female pigeon.  Skeletal Radiol . 1993;  22 473-475
  • 15 Bloom W, Bloom W A, McLean F C. Calcification and ossification, medullary bone changes in the reproductive cycles of female pigeons.  Anat Rec . 1941;  8 443-452
  • 16 King A S, McLelland J. Birds: Their Structure and Function, 2nd ed. Philadelphia, PA: Baillieres Tindall; 1984 . 
  • 17 Vananen M, Wikman L. Scurvy as a cause of osteodystrophy. Two case reports.  J Small Anim Pract . 1979;  20 491-500
  • 18 Newton C D, Biery D N. Hypertrophic osteodystrophy. In: Ettinger SJ, ed. Textbook of Veterinary Internal Medicine, 3rd ed Philadelphia, PA: W.B. Saunders 1989: 1345-1351
  • 19 Bellah J R. Hypertrophic osteodystrophy. In: Bojrab MJ, ed. Disease Mechanisms in Small Surgery, 2nd ed Philadelphia, PA: Lea & Febiger 1993: 858-864
  • 20 Olsen S E. Introduction to osteochondrosis in domestic animals.  Acta Radiol . 1975;  358(Suppl) 9-14
  • 21 Poulos P W, Reiland S, Elweinger K, Olsson S E. Skeletal lesions in the broiler chickens with special reference to dyschondroplasia (osteochondrosis).  Acta Radiol . 1978;  358(Suppl) 229-275
  • 22 Haynes J S, Walser M M, Lawler E M. Morphogensis of Fusarium sp-induced tibial dyschondroplasia in chickens.  Vet Pathol . 1985;  22 629-636
  • 23 Seawright A A, English P B. Hypervitaminosis A and hyperosteotosis in the cat.  Nature . 1965;  206 1171-1173
  • 24 Seawright A A, English P B, Gartner R JW. Hypervitaminosis A and deforming cervical spondylosis of the cat.  J Comp Pathol . 1967;  77 29-35
  • 25 Clark L. Mid-diaphyseal bone turnover during and after vitamin A toxicosis in kittens.  J Comp Pathol . 1971;  81 365-371
  • 26 Cho D Y, Frey R A, Guffy M M, Leipold H W. Hypervitaminosis A in the dog.  Am J Vet Res . 1975;  36 1597-1603