Semin Thromb Hemost 2002; 28(6): 533-538
DOI: 10.1055/s-2002-36697
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Improvement of Vitamin K Status of Breastfeeding Infants with Maternal Supplement of Vitamin K2 (MK40)

Tomizo Nishiguchi1 , Miwa Yamashita1 , Makoto Maeda2 , Kaoru Matsuyama1 , Takao Kobayashi1 , Naohiro Kanayama1 , Toshihiko Terao1
  • 1Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • 2Hamamatsu Medical Center Hospital, Hamamatsu, Japan
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Publikationsdatum:
21. Januar 2003 (online)

ABSTRACT

The present study is aimed at evaluating the efficacy of maternal vitamin K2 supplementation on the vitamin K status of newborn infants using the measurement of des-gamma-carboxyprothrombin (PIVKA-II [protein induced by vitamin K absence]) and the hepaplastin test (HPT). PIVKA-II and HPT were measured at the 1st month of age in two groups: 31 infants with maternal vitamin K supplementation (15 mg/d Menatetrenone since the 14th day after parturition) (group 1) and 46 without maternal supplementation (group 2). All infants received vitamin K2 syrup twice within the 1st week of life. The PIVKA-II levels of 31 infants (group 1) were 23.6 mAU/mL (standard deviation [SD] 5.8), showing extremely low levels, and close to healthy adult levels, with a smaller deviation than what was seen in group 2. The levels of the 46 infants in group 2 were 27.8 (SD 16.0). This does not differ significantly from group 1, but a small number of infants showed a modestly high level in PIVKA-II. There also was no significant difference between the two groups in the HPT. These data would indicate that maternal vitamin K supplementation can maintain the vitamin K status throughout the late neonatal period and prevent an onset of vitamin K-deficient hemorrhage.

REFERENCES

  • 1 Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K, and pethidine given during labor.  BMJ . 1992;  305 341-346
  • 2 Ekelund H, Finnstrom O, Gunnarskog J. Administration of vitamin K to newborn infants and childhood cancer.  BMJ . 1993;  307 89-91
  • 3 Slattery J M. Why we need a clinical trial for vitamin K.  BMJ . 1994;  308 908-910
  • 4 Hanawa Y. Studies on the prophylaxis of VK deficiency in the newborn and the infant [in Japanese]. In: Annual Report of the Comprehensive Study of Health Problems of Newborn Tokyo: The Ministry of Health and Welfare 1988: 23-27
  • 5 Hanawa Y. Vitamin K deficiency in infancy: the Japanese experience.  Acta Paediatr Jpn . 1992;  34 107-116
  • 6 Saga K, Terao T. Studies on transfer of vitamin K into human breast milk [in Japanese].  Acta Obstet Gynaecol Jpn . 1989;  41 1713-1719
  • 7 Nishiguchi T, Sumimoto K, Kobayashi T, Terao T. Prevention of vitamin K deficiency in infants. In: Nakabayashi M, Araki T, eds. Recent Advances on the Pathophysiology of Pregnancy Tokyo, Japan: Simul International Inc. 1997: 387-391
  • 8 Greer F R, Marshall S P, Foley A L, Suttie J W. Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements.  Pediatrics . 1997;  99 88-92
  • 9 Kries R V, Shearer M, McCarthy P T. Vitamin K1 content of maternal milk: influence of the stage of lactation, lipid composition and vitamin K1 supplements given to the mother.  Pediatr Res . 1987;  22 513-517
  • 10 Takatsu K, Nakanishi T, Watanabe K. An improved method for determination of des-gamma-carboxyprothrombin (PIVKA-II) using electrochemiluminescence technique; development of reagent and evaluation of its property [in Japanese].  Jpn J Clin Exp Med . 1996;  73 2656-2664
  • 11 Greer F R, Marshall S P, Severson R R. A new mixed micellar preparation for oral vitamin K prophylaxis: randomized controlled comparison with an intramuscular formulation in breast fed infants.  Arch Dis Child . 1998;  79 300-305
  • 12 Nishiguchi T, Saga K, Sumimoto K. Vitamin K prophylaxis to prevent neonatal vitamin K deficient intracranial haemorrhage in Shizuoka Prefecture.  Br J Obstet Gynecol . 1996;  103 1078-1084
  • 13 National Research Council Food and Nutrition Board. Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy Press . 1989: 107
  • 14 von Kries R, Greer F R, Suttie J W. Assessment of vitamin K status of newborn infants.  J Pediatr Gastroenterol Nutr   1993;  16 231-238
  • 15 Muntean W, Petek W, Rosanelli K. Immunologic studies on prothrombin in newborns.  Pediatr Res . 1979;  13 1262-1265
  • 16 Malia R G, Preston F E, Mitchell V E. Evidence against vitamin K deficiency in normal neonates.  Thromb Haemost . 1980;  44 159-160
  • 17 Atkinson P M, Bradlow B A, Moulineaux J D. Acarboxyprothrombin in cord plasma from normal neonates.  J Pediatr Gastroenterol Nutr . 1984;  3 450-453
  • 18 Motohara K, Endo F, Matsuda I. Effect of vitamin K administration on acarboxyprothrombin (PIVKA-II) levels in newborns.  Lancet . 1985;  11 242-244
  • 19 Sakano T, Notumoto S, Nagaoka T. Measurement of K vitamins in food by high performance liquid chromatography with fluorometric detection [in Japanese].  Vitamins (Japan) . 1988;  62 393-398
  • 20 Nishiguchi T, Saga K, Nakajima A. The relationship of maternal diet and neonatal hypoprothrombinemia-analysis of maternal background factors associated to suboptimal vitamin K status [in Japanese].  Jpn J Obstet Gynecol Neonatal Hematol . 1993;  3 27-37
  • 21 Corneilissen E AM, Kollee L AA, Abreu R D. Prevention of vitamin K deficiency in infancy by weekly administration of vitamin K.  Acta Paediatr . 1993;  82 656-659