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Semin Thromb Hemost 2002; 28(6): 529-532
DOI: 10.1055/s-2002-36696
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Influence of Low- and High-Molecular-Weight Plasminogen Activators on the Onset of Labor and on the Hemostatic System

Takanori Moriyama1 , Shigenori Suzuki2 , Kazuhiko Matsuno1 , Kiyotaka Okada3 , Osamu Matsuo3
  • 1Department of Laboratory Technology, College of Medical Technology, Hokkaido University, Sapporo, Japan
  • 2College of Medical Technology, Hokkaido University, Sapporo, Japan
  • 3Department of Physiology, Kinki University School of Medicine, Osakasayama, Japan
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Publication History

Publication Date:
21 January 2003 (online)

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ABSTRACT

Measurement of activities of urinary (u-PA) and tissue plasminogen activator (t-PA) and analysis of euglobulin lysis times (ELTs) and prekallikrein were performed simultaneously using the plasma of normal pregnant women and nonpregnant women. The activities of plasminogen activators were determined by the method of electrophoretic zymography. The activity of low-molecular-weight (LMW) u-PA was significantly decreased at the onset of labor (p = 0.05) compared with that during the latter half of pregnancy. The same tendency was observed in the analysis of prekallikrein. On the contrary, no significance was shown in activities of high-molecular-weight (HMW) u-PA or t-PA. It is suggested that the action of kallikrein on low-molecular-weight u-PA causes it to change into plasmin at the onset of labor.

KEYWORD

Tissue-type plasminogen activator (t-PA) - urinary plasminogen activator (u-PA) - zymography - hemostasis - onset of labor

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