Semin Thromb Hemost 2002; 28(6): 507-510
DOI: 10.1055/s-2002-36691
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

An Association between Maternal Smoking and Preeclampsia in Japanese Women

Gen Kobashi1 , Kaori Ohta1 , Akira Hata2 , Koichi Shido3 , Hideto Yamada4 , Seiichiro Fujimoto4 , Kiyotaro Kondo5
  • 1Department of Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo
  • 2Department of Public Health, Asahikawa Medical College, Asahikawa
  • 3Health Sciences University of Hokkaido, Ishikari
  • 4Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo
  • 5The University of the Air, Chiba, Japan
Further Information

Publication History

Publication Date:
21 January 2003 (online)

ABSTRACT

In order to determine whether maternal smoking before or during pregnancy, or both, is associated with a reduced risk for preeclampsia in Japanese subjects, we conducted a case-control study that took other risk factors for preeclampsia into consideration. Seventy-one preeclampsia patients were matched with 142 controls for parity and age. Information from a self-administered questionnaire and clinical data such as maternal age, parity, family history of hypertension, prepregnancy body mass index (BMI), and pregnancy outcomes were analyzed. No significant difference was found between the groups in smoking rates before and during pregnancy (38.0 and 18.3% in preeclampsia patients and 38.0 and 16.9% in controls, respectively). However, classification of the subjects according to the presence of "prepregnancy high body mass (BMI ≥ 24)" revealed a significant association between maternal smoking before pregnancy and preeclampsia in women with a prepregnancy high body mass (a smoking rate of 47.6% in patients with preeclampsia and 7.1% in controls, p < 0.05). This result suggests that there is a clear racial difference in the manifestation of preeclampsia with respect to the effect of smoking and that early intervention, particularly before pregnancy, to get obese women to stop smoking may be effective for preventing preeclampsia.

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