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Semin Respir Crit Care Med 2002; 23(6): 543-548
DOI: 10.1055/s-2002-36518
DOI: 10.1055/s-2002-36518
Ocular Manifestations of Sarcoidosis
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
07. Januar 2003 (online)
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ABSTRACT
Ophthalmic involvement in sarcoidosis may cause significant sight-threatening illness for patients. Studies of patients with histologically proven sarcoidosis have found 25 to 50% of patients to have ocular manifestations.[1] The frequency in which eye disease is seen and the course that it takes vary with age, race, and geography.[2] [3] This article discusses relevant aspects of the ocular manifestations of sarcoidosis for the internist and pulmonologist. Overall disease presentation, specific types of ocular involvement, evaluation strategies, and treatment considerations are discussed.
KEYWORD
iritis - uveitis - vitritis - pars planitis - scleritis - ocular manifestations - sarcoidosis
REFERENCES
- 1 Hunter D G, Foster C S. Ocular manifestations of sarcoidosis. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology Philadelphia: WB Saunders 1994: 1217-1224
- 2 Izumi T. Symposium: population differences in clinical features and prognosis of sarcoidosis throughout the world. Sarcoidosis . 1992; 9(suppl) S105-S118
- 3 Angi M R, De Caro G, Bergamo L. Low prevalence of uveitis in Italian sarcoidosis patients. Sarcoidosis . 1991; 8 181-182
- 4 Stavrou P, Foster C S. Sarcoidosis. In: Foster CS, Vitale AT, eds. Diagnosis and Treatment of Uveitis Philadelphia: WB Saunders 2002: 710-725
- 5 James D G. Ocular sarcoidosis. Ann N Y Acad Sci . 1986; 465 551-563
- 6 Raymond L A, Spaulding A G, Vilter R W. Peripheral retinal neovascularization in sarcoidosis with thalassemia. Ann Ophthalmol. 978; 10 745-748
- 7 Hoover D L, Khan J A, Giangiacomo J. Pediatric ocular sarcoidosis. Surv Ophthalmol . 1986; 30 215-228
- 8 Rothova A. Ocular involvement in sarcoidosis. Br J Ophthalmol . 2000; 84 110-116
- 9 Blau E B. Familial granulomatous arthritis, iritis, and rash. J Pediatr . 1985; 107 689-693
- 10 Manouvrier-Hanu S, Puech B, Peitte F. Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. Am J Med Gen . 1998; 76 217-221
- 11 Tromp G, Kuivaniemi H, Raphael S. Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16. Am J Hum Genet . 1996; 59 1097-1107
- 12 Siltzbach L E, James D G, Neville E. Course and prognosis of sarcoidosis around the world. Am J Med . 1974; 57 847-852
- 13 Yamaguchi M, Hosada Y, Sasaki R. Epidemiological study on sarcoidosis in Japan: recent trends in incidence and prevalence rates and changes in epidemiological features. Sarcoidosis . 1989; 6 138
- 14 Rothova A, Alberts C, Glasius E. Risk factors for ocular sarcoidosis. Doc Ophthalmol . 1989; 72 287-296
- 15 Samson C M, Waheed N, Baltatzis S. Methotrexate therapy for chronic noninfectious uveitis. Ophthalmology . 2001; 108 1134-1139
- 16 Baughman R P, Winget D B, Lower E E. Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial. Sarcoidosis Vasc Diffuse Lung Dis . 2000; 17 60-66
- 17 Baughman R P. Methotrexate for sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 1998; 15 147-149
- 18 Baughman R P, Lower E E. A clinical approach to the use of methotrexate for sarcoidosis. Thorax . 1999; 54 742-746
- 19 Dev S, McCallum R M, Jaffe G J. Methotrexate treatment for sarcoid-associated panuveitis. Ophthalmology . 1999; 106 111-118
- 20 Dana M R, Merayo-Lloves J, Schaumberg D A. Prognosticators for visual outcome in sarcoid uveitis. Ophthalmology . 1996; 103 1846-1853
- 21 Baughman R P, Lower E E, Bradley D A, Kaufman A H. Use of cytotoxic therapy for chronic ophthalmic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 1999; 16(suppl) S17
- 22 Baughman R P, Ohmichi M, Lower E E. Combination therapy for sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 2001; 18 133-137
- 23 Edelsten C, Pearson A, Joynes E. The ocular and systemic prognosis of patients presenting with sarcoid uveitis. Eye . 1999; 13(pt 6) 748-753
- 24 Kaye G B, Salmon J F, Isaacs S. Risk factors for uveitis in sarcoidosis. S Afr Med J . 1993; 83 342-344
- 25 Jabs D A, Johns C J. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol . 1986; 102 297-301
- 26 Martinetti M, Tinelli C, Kolek V. ``The Sarcoidosis Map'': a joint survey of clincal and immunogenetic findings in two European countries. Am J Respir Crit Care Med . 1995; 152 557-564
- 27 Merritt J C, Whitsett C F, Daffin L. HLA-A, -B, and -DR antigenic factors in ocular sarcoidosis. Am J Ophthalmol . 1983; 96 396-397
- 28 Baughman R P, Teirstein A S, Judson M A. A Case Control Etiologic Study of Sarcoidosis (ACCESS) Research Group. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med . 2001; 164 1885-1889
- 29 Rothova A, Suttorp-van Schulten S M, Frits T W. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol . 1996; 80 332-336
- 30 Dresner M S, Brecher R, Henkind P. Ophthalmology consultation in the diagnosis and treatment of sarcoidosis. Arch Intern Med . 1986; 146 301-304
- 31 Hunninghake G W, Costabel U, Ando M. ATS/ ERS/WASOG statement on sarcoidosis. Am J Resp Crit Care Med 1999;160:736-755; Sarcoidosis Vasc Diffuse Lung Dis . 1999; 16 149-173
- 32 Johns C J, Michele T M. The clinical management of sarcoidosis: a 50-year experience at the Johns Hopkins Hospital. Medicine (Baltimore) . 1999; 78 65-111
- 33 Obenauf C D, Shaw H E, Sydnor C F. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol . 1978; 86 648-655