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DOI: 10.1055/s-2002-35510
Mnestische Störungen unter Olanzapinüberdosierung bei einem älteren Patienten
Mnestic Impairment under Olanzapine Overdosage in an Elderly PatientPublication History
Publication Date:
18 November 2002 (online)
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Zusammenfassung
Atypische Antipsychotika werden in zunehmendem Ausmaß auch für die Behandlung älterer Patienten eingesetzt. Es liegen bislang allerdings nur wenige Untersuchungen über ihre Wirksamkeit und Nebenwirkungen bei dieser Patientengruppe vor. Es wird über einen 67-jährigen Patienten berichtet, bei dem es unter Behandlung mit Olanzapin in üblicher Dosierung zu einem Anstieg des Serumspiegels weit über den therapeutischen Bereich kam. Diese Olanzapinüberdosierung war begleitet von ausgeprägten Gedächtnisstörungen für visuelles und verbales Material und von einer mittelschweren Allgemeinveränderung im EEG. Beide Veränderungen lassen sich auf die anticholinerge Wirkung von Olanzapin zurückführen und bildeten sich nach Dosisreduktion und Normalisierung des Olanzapinserumspiegels rasch zurück.
Abstract
Atypical antipsychotics are increasingly used for the treatment of elderly patients. However, there are only few studies on their efficacy and side effects in this patient group. The case of a 67-year old patient is presented, in whom under treatment with olanzapine in usual dosage, serum level increased into the toxic range. This olanzapine overdosage was accompanied by severe impairments in visual and verbal memory and by an increase of slow-frequency activity in the EEG. Both alterations may be attributed to the anticholinergic effects of olanzapine and reversed rapidly after dose reduction and normalization of the olanzapine serum level.
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Prof. Dr. Georg Adler
Altentagesklinik am Zentralinstitut für Seelische Gesundheit
J5
68159 Mannheim
Email: adler@zi-mannheim.de