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Psychother Psychosom Med Psychol 2002; 52(11): 469-478
DOI: 10.1055/s-2002-35276
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Differente Muster regionaler Hirnaktivität nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen

Eine positronenemissionstomographische (PET-)Studie mit 15O-H2O und emotionaler Stimulierung durch autobiografische ErinnerungDifferent Patterns of Regional Brain Activation During Emotional Stimulation in Alexithymics in Comparison with Normal ControlsA Positron Emission Tomography (PET) Study with 15O-H2O and Emotional Stimulation by Way of Autobiographic RecallMichael  Huber1 , Karl  Herholz2 , Birgit  Habedank1 , Alexander  Thiel2 , Markus  Müller-Küppers3 , Hermann  Ebel3 , Claudia  Subič-Wrana1 , Karl  Köhle1 , Wolf-Dieter  Heiss2
  • 1Institut und Poliklinik für Psychosomatik und Psychotherapie der Universität zu Köln
  • 2Max-Planck-Institut für Neurologische Forschung, Köln
  • 3Psychiatrische Universitätsklinik der RWTH Aachen
Further Information

Publication History

Eingegangen: 25. April 2002

Angenommen: 20. August 2002

Publication Date:
05 November 2002 (online)

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Zusammenfassung

Unter Verwendung von 15O-H2O-Positronenemissionstomographie und einem autobiografischen emotionalen Stimulationsparadigma wurden 9 Patienten mit somatoformen Störungen ohne sonstige Achse-I- oder Achse-II-Störung nach dem DSM-IV und hohen TAS-20-Werten (Toronto-Alexithymie-Skala) mit 10 Normalpersonen verglichen. Unter Stimulationsbedingungen (Trauer, Freude) zeigten Normalpersonen stärkere Aktivierungen als Alexithyme in zingulären Arealen, dem Corpus callosum sowie rechtsseitigen Frontalregionen. Alexithyme aktivierten stärker Kuneus und Präkuneus, Thalamus (Pulvinar), linksseitig mediale frontale und rechtsseitige frontale Regionen, die rechtsseitige Präzentralregion sowie das Zerebellum. Das Merkmal der Alexithymie ist in dieser Untersuchung unter emotionaler Stimulation verbunden mit einer Aktivierung sprachassoziierter Regionen, während limbische und paralimbische Strukturen signifikant weniger in Anspruch genommen werden als dies bei Normalpersonen der Fall ist.

Abstract

Objective: This study was designed to determine patterns of regional brain activation during emotional stimulation in alexithymics as compared with normal controls. Method: We used 15O-water positron emission tomography and an emotional stimulation paradigm based upon autobiographic recall of either happy, sad or emotionally neutral situations. 10 normal subjects without medical or psychiatrical history were compared with 9 patients with somatoform disorder without any other DSM-IV diagnosis. TAS-20 was used as a measure for alexithymia, depression was measured using BDI. Results: Normal controls showed significantly greater activation than alexithymics in cingulate areas, corpus callosum, and right superior and inferior frontal gyrus. Alexithymics activated significantly more in cuneus and precuneus, thalamus (pulvinar), left medial frontal, right inferior temporal, left superior temporal regions, left precentral gyrus, and the cerebellum. Conclusions: During emotional autobiographic recall, alexithymia, either trait or state, is characterized by utilization of different brain regions when compared to normal controls. The areas activated by alexithymic persons largely comprise of language related regions, leaving out limbic and paralimbic areas.

Key words

Alexithymia - emotion

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Priv.-Doz. Dr. med. Michael Huber

Institut und Poliklinik für Psychosomatik und Psychotherapie der Universität zu Köln

50924 Köln

Email: Michael.Huber@Uni-Koeln.de

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