RSS-Feed abonnieren
DOI: 10.1055/s-2002-34930
Hepatoprotective and Free Radical Scavenging Activities of Prenylflavonoids, Coumarin, and Stilbene from Morus alba
Publikationsverlauf
Received: February 1, 2002
Accepted: June 15, 2002
Publikationsdatum:
21. Oktober 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200210/lookinside/thumbnails/10.1055-s-2002-34930-1.jpg)
Abstract
Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC50 values of 19.1 ± 3.6 and 3.81 ± 0.5 μM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC50 = 23.4 ± 1.5 μM). Compounds 2 and 4 showed hepatoprotective effects with EC50 values of 10.3 ± 0.42 and 32.3 ± 2.62 μM, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
References
- 1 Bast A, Haenen G, Doelman C. Oxidants and antioxidants: state of the art. The American Journal of Medicine. 1991; 91 Suppl 3C 2-13
- 2 Bulkley G B. Free radicals and other reactive oxygen metabolites: clinical relevance and the therapeutic efficacity of antioxidant therapy. Surgery. 1993; 113 479-83
- 3 Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause or consequence?. Lancet. 1994; 344 721-4
-
4 Kappus H. Lipid peroxidation: mechanisms, enzymology and biological relevance. In: Sies H, editor
Oxidative Stress . Academic Press London; 1985: 273-310 - 5 Kappus H. Oxidative stress in chemical toxicity. Archives of Toxicology. 1987; 60 144-9
- 6 Zhu Y P. Chinese Materia Medica: Chemistry, Pharmacology and Applications. Amsterdam; Harwood Academic Publishers 1998: 273-4
- 7 Fujimoto T, Hano Y, Nomura T, Uzawa J. Components of root bark of Cudrania tricuspidata 2. Structures of two new isoprenylated flavones, cudraflavones A and B. Planta Medica. 1984; 50 161-3
- 8 Hano Y, Matsumoto Y, Shinohara K, Sun J Y, Nomura T. Cudraflavones C and D, two new prenylflavones from the root bark of Cudrania tricuspidata (Carr.) Bur. Heterocycles. 1990; 31 1339-44
- 9 Song E K, Cho H, Kim J S, Kim N Y, An N H, Kim J A, Lee S H, Kim Y C. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa . Planta Medica. 2001; 67 876-7
Prof. Dr. Youn-Chul Kim
MRRC and College of Pharmacy
Wonkwang University
Iksan 570-749
South Korea
eMail: yckim@wonkwang.ac.kr
Fax: +82-63-852-8837