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DOI: 10.1055/s-2002-34921
© Georg Thieme Verlag Stuttgart · New York
Cytotoxic ent-Kaurane Diterpenoids from Isodon sculponeata
Publikationsverlauf
Received: February 22, 2002
Accepted: May 18, 2002
Publikationsdatum:
21. Oktober 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200210/lookinside/thumbnails/10.1055-s-2002-34921-1.jpg)
Abstract
Four new ent-kaurane diterpenoids, sculponeatins F-I (1 - 4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2α,3β-dihydroxy-urs-12-en-28-oic acid, 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid, β-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 μg/ml to 8.2 μg/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
Key words
Isodon sculponeata - Labiatae - diterpenoids - sculponeatins F-I - cytotoxicity
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Prof. Dr. Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
The Chinese Academy of Sciences
Heilongtan, Kunming 650204
People’s Republic of China
eMail: hdsun@mail.kib.ac.cn
Fax: +86 871 5216343