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Am J Perinatol 2002; 19(6): 297-302
DOI: 10.1055/s-2002-34468
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Akinesia, Arthrogryposis, Craniosynostosis: A Presentation of Neonatal Myasthenia with Fetal Onset

Sylvain Cantagrel1 , Laure Maury1 , Anne-Marie Yamamoto2 , Josette Maheut3 , Annick Toutain4 , Pierre Castelnau3
  • 1Pediatric and Neonatal Intensive Care Unit, Clocheville Children's Hospital, Tours, France
  • 2Immunology Laboratory, Necker Children's Hospital, Paris, France
  • 3Pediatric Neurology Unit, Clocheville Children's Hospital, Tours, France
  • 4Genetic Unit, Bretonneau Hospital,Tours, France
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Publication History

Publication Date:
01 October 2002 (online)

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ABSTRACT

Major akinesia with arthrogryposis and craniosynostosis at birth mimics irreversible disorders of the nervous system of pejorative outcome. In this context, the early detection of anti-acetylcholine fetal receptor antibodies in the mother may allow rapid diagnosis of transient neonatal myasthenia of favorable prognosis.

KEYWORDS

Arthrogryposis - craniosynostosis - fetal - myasthenia

REFERENCES

  • 1 Aicardi J. Disease of the Nervous System in Childhood.  2nd ed. London: Cambridge University Press 1998: 750-790
    Google Scholar
  • 2 Eymard B. Neonatal myasthenia gravis clinical and pathophysiological aspects.  Adv Organ Biol . 1997;  2 235-247
    PubMedGoogle Scholar
  • 3 Tranchant C, Ehret C, Labouret P, Gasser B, Warter J M. Arthrogrypose et myasthenie maternelle: risque de récurrence.  Rev Neurol . 1991;  147 63-64
    PubMedGoogle Scholar
  • 4 Dinger J, Prager B. Arthrogryposis multiplex in a newborn of a myasthenic mother: case report and literature.  Neuromusc Disord . 1993;  3 335-339
    PubMedGoogle Scholar
  • 5 Moutard-Coudou M L, Delleur M M, Dulac O. Myasthénie neonatale sevère avec arthrogrypose.  Presse Med . 1987;  16 615-618
    PubMedGoogle Scholar
  • 6 Vernet-der Garabedian B, Lacokova M, Eymard B. Association of neonatal myasthenia gravis with antibodies against the fetal acetylcholine receptor.  J Clin Invest . 1994;  94 555-559
    PubMedGoogle Scholar
  • 7 Vincent A, Newland C, Brueton L. Arthrogryposis multiplex congenita with maternal autoantibodies specific for a fetal antigen.  Lancet . 1995;  346 24-25
    CrossrefPubMedGoogle Scholar
  • 8 Barnes P R, Kanabar D J, Brueton L, Newsom-Davis J, Huson S M, Mann N P, Hilton-Jones D. Recurrent congenital arthrogryposis leading to a diagnosis of myasthenia gravis in an initially asymptomatic mother.  Neuromuscul Disord . 1995;  5 59-65
    CrossrefPubMedGoogle Scholar
  • 9 McIntosh I, Bellus G A, Jab E W. The pleiotropic effects of fibroblast growth factor receptors in mammalian development.  Cell Struct Funct . 2000;  25 85-96
    CrossrefPubMedGoogle Scholar
  • 10 Graham J M, Badura R J, Smith D W. Coronal craniostenosis: fetal head constraint as one possible cause.  Pediatrics . 1980;  65 995-999
    PubMedGoogle Scholar
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