Download PDF
Am J Perinatol 2002; 19(6): 333-340
DOI: 10.1055/s-2002-34467
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Neonatal and Maternal Serum Levels of Soluble ICAM-1 in Preeclamptic and Normal Pregnancies

Didem Aliefendioğlu1 , Gülşen Erdem2 , Necla Tülek3 , Murat Yurdakök2
  • 1Neonatology Unit, Social Security Children's Hospital, Ankara, Turkey
  • 2Neonatology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
  • 3Health Ministry Training and Research Hospital, Ankara, Turkey
Further Information

Publication History

Publication Date:
01 October 2002 (online)

    Permissions and Reprints

ABSTRACT

The aim of this study is to determine whether circulating levels of sICAM-1 were changed in infants of preeclamptic mothers, and factors influencing these levels. Peripheral venous blood samples were obtained from preeclamptic and nonpreeclamptic pregnant women (control) and their babies in the first 2 hours post partum. The enzyme-linked immunoadsorbent assay (ELISA) technique was used to determine concentrations of sICAM-1. Compared with the control group, maternal and neonatal serum sICAM-1 levels were higher in the preeclamptic group. Neonatal levels were correlated with the maternal levels only, and there were no difference between premature and term babies and their mothers. In the control group, on the other hand, premature babies and their mothers had higher sICAM-1 levels than term babies and their mothers, with values close to those of premature group in the preeclamptic group. Neonatal sICAM-1 levels were correlated with gestational age, birth weight, and also with maternal levels. Linear regression analysis of these parameters, however, showed that only the gestational age was significant. The study suggests that perinatal sICAM-1 levels possibly are not independent from the maternal levels. High sICAM-1 levels in infants of preeclamptic mothers and premature babies might reflect the high maternal levels.

KEYWORDS

Adhesion molecule - sICAM-1 - preeclampsia

REFERENCES

  • 1 Gearing A JH, Newman W. Circulating adhesion molecules in disease.  Immunol Today . 1993;  14 506-512
    CrossrefPubMedGoogle Scholar
  • 2 Etzioni A. Adhesion molecules: their role in health and disease.  Pediatr Res . 1996;  39 191-198
    PubMedGoogle Scholar
  • 3 Nash M C, Wade M, Shah V, Dillon M J. Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease with age.  Clin Exp Immunol . 1996;  103 167-170
    CrossrefPubMedGoogle Scholar
  • 4 Küster H, Degitz K. Circulating ICAM-1 in neonatal sepsis [letter].  Lancet . 1993;  341 506
    PubMedGoogle Scholar
  • 5 Austgulen R, Arntzen K J, Haereid P E, Aag S, Dollner H. Infections in neonates delivered at term are associated with increased serum levels of ICAM-1 and E-selectin.  Acta Paediatr . 1997;  86 274-280
    PubMedGoogle Scholar
  • 6 Ramsay P L, Smith E O, Hegemier S, Welty S E. Early clinical markers for the development of bronchopulmonary dysplasia: soluble E-Selectin and ICAM-1.  Pediatrics . 1998;  102 927-932
    PubMedGoogle Scholar
  • 7 Zuspan F P, Samuel P. Preventing preeclampsia.  N Engl J Med . 1993;  329 1265-1266
    CrossrefPubMedGoogle Scholar
  • 8 Davidge S T, Signorella A P, Lykins D L, Gilmour C H, Roberts J M. Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women.  Am J Obstet Gynecol . 1996;  175 1301-1306
    PubMedGoogle Scholar
  • 9 Roberts J M, Redman C W. Pre-eclampsia: more than pregnancy induced hypertension.  Lancet . 1993;  341 1447-1451
    CrossrefPubMedGoogle Scholar
  • 10 Austgulen R, Lien E, Vince G, Redman W G. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia.  Eur J Obst Gynecol Reprod Biol . 1997;  71 53-58
    CrossrefPubMedGoogle Scholar
  • 11 Lyall F, Greer I A, Boswell F, Macara L M, Walker J J, Kingdom J C. The cell adhesion molecule, VCAM-1, is selectively elevated in serum in pre-eclempsia: does this indicate the mechanism of leucocyte activation?.  Br J Obstet Gynaecol . 1994;  101 485-487
    PubMedGoogle Scholar
  • 12 Krauss T, Kuhn W, Lakoma C, Augustin H G. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk of developing preeclampsia.  Am J Obstet Gynecol . 1997;  177 443-449
    PubMedGoogle Scholar
  • 13 Krauss T, Azab H, Dietrich M, Augustin H G. Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies.  Eur J Obstet Gynecol Reprod Biol . 1998;  78 41-45
    CrossrefPubMedGoogle Scholar
  • 14 Redman C W, Sacks G P, Sargent I L. Preeclampsia: an excessive maternal inflammatory response to pregnancy.  Am J Obstet Gynecol . 1999;  180 499-506
    CrossrefPubMedGoogle Scholar
  • 15 Walker J J. Pre-eclampsia.  Lancet . 2000;  356 1260-1265
    CrossrefPubMedGoogle Scholar
  • 16 Roberts J M, Redman C W. Pre-eclampsia: more than pregnancy induced hypertension.  Lancet . 1993;  341 1447-1451
    CrossrefPubMedGoogle Scholar
  • 17 Davey D A, MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy.  Am J Obstet Gynecol . 1988;  158 892-898
    CrossrefPubMedGoogle Scholar
  • 18 Carlos T M, Harlan J M. Leucocyte-endothelial adhesion molecules.  Blood . 1994;  84 2068-2101
    PubMedGoogle Scholar
  • 19 Bessler H, Kuperman A, Beilin B. Labor affects cytokine production in newborns.  Am J Reprod Immunuol . 1998;  39 27-32
    PubMedGoogle Scholar
  • 20 Hata T, Kawamura T, Inada K. Cord blood cytokines and soluble adhesion molecules in vaginal and cesarean delivered neonates.  Gynecol Obstet Invest . 1996;  42 102-104
    PubMedGoogle Scholar
  • 21 Keelan J A, Marvin K W, Sato T A, Coleman M, McCowan L M, Mitchell M D. Cytokine abundance in placental tissues: evidence of inflammatory activation in gestational membranes with term and preterm parturition.  Am J Obstet Gynecol . 1999;  181 1530-1536
    CrossrefPubMedGoogle Scholar
  • 22 Marvin K W, Keelan J A, Sato T A. Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labour.  Placenta . 2000;  21 115-121
    CrossrefPubMedGoogle Scholar
  • 23 Kume N, Cybulsky M I, Gimbrone Jr A M. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leucocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.  J Clin Invest . 1992;  90 1138-1146
    CrossrefPubMedGoogle Scholar
  • 24 Romero R, Sepulveda W, Baumann P. The preterm labor syndrome: biochemical, cytologic, immunologic, pathologic, microbiologic, and clinical evidence that preterm labor is a heterogeneous disease.  Am J Obstet Gynecol . 1993;  168 288-292
    PubMedGoogle Scholar
  • 25 Murtha A P, Greig P C, Jimmerson C E, Herbert W N. Maternal serum interleukin-6 concentration as a marker for impending preterm delivery.  Obstet Gynecol . 1998;  91 161-164
    CrossrefPubMedGoogle Scholar
  • 26 van de Stolpe A, van der Saag T P. Intercellular adhesion molecule-1.  J Mol Med . 1996;  74 13-33
    PubMedGoogle Scholar
  • 27 Steinborn A, Sohn C, Heger S, Niederhut A, Hildenbrand R, Kaufman M. Labour-associated expression of intercellular adhesion molecule-1 (ICAM-1) in placental endothelial cells indicates participation of immunological processes in parturition.  Placenta . 1999;  20 567-573
    CrossrefPubMedGoogle Scholar
      >