Planta Med 2002; 68(9): 841-843
DOI: 10.1055/s-2002-34403
Letter
© Georg Thieme Verlag Stuttgart · New York

Flavonoids and Stilbenoids with COX-1 and COX-2 Inhibitory Activity from Dracaena loureiri

Kittisak Likhitwitayawuid1 , Kanokporn Sawasdee1 , Kanyawim Kirtikara2
  • 1Department of Pharmacognosy, Faculty of Pharmaceutical Sciences Chulalongkorn University, Bangkok, Thailand
  • 2National Center for Genetic Engineering and Biotechnology, Bangkok, Thailand
Further Information

Publication History

Received: November 16, 2001

Accepted: April 6, 2002

Publication Date:
30 September 2002 (online)

Abstract

Fom the stem wood of Dracaena loureiri, a new homoisoflavanone named loureiriol (1) and eight known flavonoid and stilbenoid derivatives, including 5,7-dihydroxy-3-(4-hydroxybenzyl)-4-chromanone (2), 4,4′-dihydroxy-2,6-dimethoxydihydrochalcone (3), 2,4′-dihydroxy-4,6-dimethoxydihydrochalcone (4), 4′-hydroxy-2,4,6-trimethoxydihydrochalcone (5), 4,6,4′-trihydroxy-2-methoxydihydrochalcone (6), 4,3′,5′-trihydroxystilbene (7), 4,3′-dihydroxy-5′-methoxystilbene (8) and 4-hydroxy-3′,5′-dimethoxystilbene (9) were isolated. These compounds were evaluated for their inhibitory activity against the enzymes cyclooxygenase-1 and cyclooxygenase-2. Potent but non-selective activity was found for the stilbenoids 7 - 9 (IC50 1.29 - 4.92 μM) whereas weak or no activity was observed for the flavonoids 1 - 6.

References

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Kittisak Likhitwitayawuid, Ph. D.

Department of Pharmacognosy

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Bangkok 10330, Thailand

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Fax: +66-2255-8227