Planta Med 2002; 68(9): 847-850
DOI: 10.1055/s-2002-34400
Letter
© Georg Thieme Verlag Stuttgart · New York

Effects of Chronic Chrysin Treatment in Spontaneously Hypertensive Rats

Inmaculada Concepción Villar1 , Rosario Jiménez1 , Milagros Galisteo1 , Maria Francisca Garcia-Saura1 , Antonio Zarzuelo1 , Juan Duarte1
  • 1Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
Further Information

Publication History

Received: December 10, 2001

Accepted: March 29, 2002

Publication Date:
30 September 2002 (online)

Abstract

The effects of an oral daily dose (20 mg kg-1) of the flavonoid chrysin for 6 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. Chrysin reduces SHR elevated blood pressure, cardiac hypertrophy and functional vascular changes, but is without effect in WKY. These protective effects were associated with a reduced oxidative status due to the antioxidant properties of the drug.

Abbreviations

MDA:total plasma malondialdehyde

SBP:systolic blood pressure

SHR:spontaneously hypertensive rat

WKY:Wistar Kyoto rat

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Prof. Dr. Juan Duarte

Department of Pharmacology

School of Pharmacy

University of Granada

18071 Granada

Spain

Phone: +34-958243889

Fax: +34-958248964

Email: jmduarte@ugr.es