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Synthesis 2002(14): 2096-2104
DOI: 10.1055/s-2002-34379
DOI: 10.1055/s-2002-34379
PAPER
© Georg Thieme Verlag Stuttgart · New York
Determination of the Relative Configuration of the C-2-C-1′-Fragment of Cytostatin
Weitere Informationen
Received
6 June 2002
Publikationsdatum:
26. September 2002 (online)
Publikationsverlauf
Publikationsdatum:
26. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/200214SpecialIssue/lookinside/thumbnails/10.1055-s-2002-34379-1.jpg)
Abstract
Four diastereomers of a simple subtructure of cytostatin containing the α,β-unsaturated lactone subunit were synthesized and their NMR-spectroscopical data were compared with values recorded for the natural product in order to unravel the relative stereochemistry in cytostatin.
Key words
natural products - lactones - aldol reactions - asymmetric synthesis - phosphatases
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