Synlett 2002(10): 1595-1606
DOI: 10.1055/s-2002-34233
ACCOUNT
© Georg Thieme Verlag Stuttgart · New York

Chiral Titanium Complexes. Synthesis of Optically Active Unsaturated Alcohols, Diols, Polypropionates and their Use in the Synthesis of Biologically Active Compounds

Janine Cossy*, Samir BouzBouz, Fabienne Pradaux, Catherine Willis, Véronique Bellosta
Laboratoire de Chimie Organique Associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05 - France.
Fax: +33(1)40794660; e-Mail: janine.cossy@espci.fr;
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Publikationsverlauf

Received 5 December 2001
Publikationsdatum:
23. September 2002 (online)

Abstract

Enantiopure allyltitanium and crotyltitanium complexes allow the enantioselective synthesis of 1,2-, 1,3- and 1,5-diols as well as polypropionate units. These complexes can be used in the synthesis of a great number of biologically active compounds.

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The enantiomeric excesses were determined by HPLC analysis (Waters 590 chromatograph coupled with a Varian UV detector λ = 220 nm), Chiralcel-AD2, Chiralpak-AD2, Chiralcel-OD-H or Chiralpak-OD-H column (hexane/isopropanol or hexane/ethanol).