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Synlett 2002(10): 1595-1606
DOI: 10.1055/s-2002-34233
DOI: 10.1055/s-2002-34233
ACCOUNT
© Georg Thieme Verlag Stuttgart · New York
Chiral Titanium Complexes. Synthesis of Optically Active Unsaturated Alcohols, Diols, Polypropionates and their Use in the Synthesis of Biologically Active Compounds
Weitere Informationen
Received
5 December 2001
Publikationsdatum:
23. September 2002 (online)
Publikationsverlauf
Publikationsdatum:
23. September 2002 (online)
![](https://www.thieme-connect.de/media/synlett/200210/lookinside/thumbnails/10.1055-s-2002-34233-1.jpg)
Abstract
Enantiopure allyltitanium and crotyltitanium complexes allow the enantioselective synthesis of 1,2-, 1,3- and 1,5-diols as well as polypropionate units. These complexes can be used in the synthesis of a great number of biologically active compounds.
Key words
allyltitanation - crotyltitanation - enantioselectivity - diols - polypropionates - natural products
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References
The enantiomeric excesses were determined by HPLC analysis (Waters 590 chromatograph coupled with a Varian UV detector λ = 220 nm), Chiralcel-AD2, Chiralpak-AD2, Chiralcel-OD-H or Chiralpak-OD-H column (hexane/isopropanol or hexane/ethanol).