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Synthesis 2002(13): 1813-1818
DOI: 10.1055/s-2002-33905
DOI: 10.1055/s-2002-33905
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Synthetic Access to δ-Amino-γ,γ-difluoro-β-ketoesters
Weitere Informationen
Received
30 April 2002
Publikationsdatum:
09. September 2002 (online)
Publikationsverlauf
Publikationsdatum:
09. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/200213/lookinside/thumbnails/10.1055-s-2002-33905-1.jpg)
Abstract
The zinc-cuprous chloride promoted Reformatsky-imine addition reaction of 4-bromo-4,4-difluoroacetoacetate with aldimines derived from aromatic aldehydes and with ketimines derived from aryl alkyl ketone provided an efficient and practical access to δ-amino-γ,γ-difluoro-β-ketoesters. The scope and limitation of this procedure are also discussed.
Key words
difluorinated amines - imines - zinc - cuprous chloride - 4-bromo-4,4-difluoroacetoacetate
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References
Some of the signals in aryl and alkene region are not assigned in 13C NMR spectra due to complexity, since the spectrum is obtained from a mixture of keto ester enol ester and hydrate form.