Subscribe to RSS
DOI: 10.1055/s-2002-33850
6-Minuten-Gehtest in der pneumologischen und kardiologischen Diagnostik
Methodik, Bedeutung und GrenzenSix-Minute Walk Test in Chronic Lung and Heart DiseaseTechnical Aspects, Interpretation, LimitationsPublication History
Publication Date:
06 September 2002 (online)
Einleitung
Patienten mit chronischen Lungenerkrankungen oder Herzinsuffizienz sind in ihrer Belastbarkeit eingeschränkt. Diesen beiden Patientengruppen kommt eine große epidemiologische und ökonomische Bedeutung zu. Die COPD ist verantwortlich für 5 % aller ambulanten Arztbesuche und mehr als 13 % aller Krankenhauseinweisungen [3]. In der Mortalitätsreihung nimmt die COPD den 3. Platz ein, an der Morbidität gemessen Platz 5. 15 % der Kosten im Gesundheitssystem verursachen die Lungenerkrankungen, diese angeführt von der COPD [4]. Der 6-Minuten-Gehtest (6MGT) hilft, die funktionellen Reserven und das Ausmaß der Belastbarkeit von Patienten mit chronischen Lungen- und Herzerkrankungen in ihrem individuellen Alltag zu beurteilen, und dies in unkomplizierter Weise.
Klassische Ergometrieuntersuchungen auf dem Fahrrad oder auf dem Laufband sind gerade für ältere, gebrechliche oder schwergradig limitierte Menschen in aller Regel ungeeignet. Derartige Funktionsuntersuchungen spiegeln somit die Belastbarkeit im Alltag bei den genannten Patientengruppe nicht wider. Der 6MGT ist hierfür der geeignetere Maßstab [1].
Versuche mit Hilfe des 6MGT die Prognose bzw. Überlebenszeit, die Operabilität für Lungenteilresektionen oder die Indikation zur Lungentransplantation zu beurteilen, zeigen statistisch Korrelationen bzw. diskriminieren über alle Schweregrade chronischer Lungenerkrankungen. Die Voraussetzungen, die erlauben die statistische Auswertung ganzer Gruppen auf eine individuelle, klinisch-relevante Einschätzung zu übertragen, sind allerdings nicht gegeben [2].
Die Hauptvorteile des 6MGT sind dessen Einfachheit, der geringe Aufwand an Ressourcen (Korridor, Supervision) und die Möglichkeit, den 6MGT nahezu überall anwenden zu können. Eine finanzielle Investition, eine spezielle technische Ausstattung oder ein hoher personeller Einsatz sind nicht erforderlich [5].
Literatur
- 1 Guyatt G H, Sullivan M J, Thompson P J. et al . The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985; 13; 132 (8) 919-923
- 2 Solway S, Brooks D, Lacasse Y. et al . A qualitative systematic overview of the measurement properties of functional walk tests used in cardiorespiratory domain. Chest. 2001; 119 256-270
- 3 Feinleib M, Rosenberg H M, Collins J G. et al . Trends in COPD morbidity and mortality in the United States. Am Rev Respir Dis. 1989; 140 9-18
- 4 Morr H. Respiratory insufficiency. Epidemiology, economic burden and health care facilities needed as exemplified by COPD. Internist. 2001; 42 (3) 373-378
- 5 Singh S J. The use of field walking tests of assessment of functional capacity in patients with chronic airway obstruction. Physiotherapy. 1992; 78 102-104
- 6 Guyatt G H, Pugsley S O, Sullivan M J. et al . Effect of encouragement on walkung test performance. Thorax. 1984; 39 818-822
- 7 Stevens D, Elpern E, Sharma K. et al . Comparison of hallway and treadmill six-minute walk test. Am J Respir Crit Care Med. 1999; 160 1540-1543
- 8 Knox A J, Morrison J F, Muers M F. Reproducibility of walking test results in chronic obstructive pulmonary disease. Thorax. 1988; 43 388-392
- 9 Gibbons W J, Fruchter N, Sloan S. et al . Reference values for a multiple repetition 6-minute walk test in healthy adults older than 20 years. J Cardiopulm Rehabil. 2001; 21 87-93
- 10 Enright P L, Sherrill D L. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med. 1998; 158 1384-1397
- 11 Troosters T, Gosselink R, Decramer M. Six minute walking distance in healthy elderly subjects. Eur Respir J. 1999; 13 270-274
- 12 Lipkin D P, Scriven A J, Crake T. et al . Six minute walking for assessing exercise capacity in chronic heart failure. BMJ. 1986; 292 653-655
- 13 Leger L A, Lambert J. A maximal multistage 20-m shuttle run test to prodict VO2max. Eur J Appl Physiol. 1982; 49 1-12
- 14 Forte S, Carlone S, Onorati P. et al . Shuttle test versus 6-minute walking test in evaluation of exercise tolerance in COPD patients. Eur Respir J. 1997; 10 177
- 15 Morales F J, Martinez A, Mendez M. et al . A shuttle walk test for assessment of functional capacity in chronic heart failure. Am Heart J. 1999; 138 291-298
- 16 Singh S J, Morgan M DL, Scott S. et al . Development of a shuttle walking test of disability in patients with chronic airflow obstruction. Thorax. 1992; 47 1019-1024
- 17 Deutsche Gesellschaft für Pneumologie . Empfehlungen zur Durchführung und Bewertung von Belastungsuntersuchungen in der Pneumologie. Pneumologie. 1998; 52 225-231
- 18 Singh S J, Morgan M D, Hardman A E. et al . Comparison of oxygen uptake during a conventional treadmill test and the shuttle walking test in chronic airflow limitation. Eur Respir J. 1994; 7 2016-2020
- 19 Revill S M, Morgan M DL, Singh S J. et al . The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax. 1999; 54 213-222
- 20 Butland R J, Pang J, Gross E R. et al . Two-, six, and 12-minute walking tests in respiratory disease. BMJ. 1982; 284 1607-1608
- 21 Bernstein M L, Despars J A, Singh N P. et al . Reanalysis of the 12-min walk in patients with chronic obstructive pulmonary disease. Chest. 1994; 105 163-167
- 22 Larson J L, Covey M K, Vitalo C A. et al . Reliability and validity of the 12-minute distance walk in patients with chronic obstructive pulmonary disease. Nurs Res. 1996; 45 203-210
- 23 McGavin C R, Gupta S P, McHardy G JR. Twelve-minute walking test for assessing disability in chronic bronchitis. BMJ. 1976; 1 201-204
- 24 Mungall I PF, Hainsworth R. Assessment of respiratory function in patients with chronic obstructive airway disease. Thorax. 1979; 34 254-258
- 25 Alison J A, Anderson S D. Comparison of two methods of assessing physical performance in patients with chronic airway obstruction. Phys Ther. 1981; 61 1278-1280
- 26 O'Reilly J F, Shaylor J M, Fromings K M. et al . The use of the 12 minute walking test in assessing the effect of oral steroid therapy in patients with chronic airway obstruction. Br J Dis Chest. 1982; 76 374-382
- 27 Swinburn C R, Wakefield J M, Jones P W. Performance, ventilation, and oxygen consumption in threee different types of exercise test in patients with chronic obstructive lung disease. Thorax. 1985; 40 581-586
- 28 Dekhuyzen P NR, Kaptein A A, Decker F W. et al . Twelve-minute walking test in a group of Dutch patients with chronic obstructive pulmonary disease: relationship with functional capacity. Eur J Respir Dis Suppl. 1986; 69 259-264
- 29 Gerardi D A, Lovett L, Benoit-Connors M L. et al . Variables related to increased mortality following out-patient pulmonary rehabilitation. Eur Respir J. 1996; 9 431-435
- 30 Casaburi R. Exercise training in chronic obstructive lung disease. In: Casaburi R, Petty TL, eds. Principles and practice of pulmonary rehabilitation. Philadelphia: W. B. Saunders 1993: 204-224
- 31 Casaburi R, Patessio A, Ioli F. et al . Reduction in exercise lactic acidosis and ventilation as result of exercise training in patients with obstructive lung disease. Am Rev Respir Dis. 1991; 143 9-18
- 32 Donner C F, Muir J F. Selection criteria and programmes for pulmonary rehabilitation in COPD patients. Rehabilitation and Chronic Care Scientific Group of the European Respiratory Society. Eur Respir J. 1997; 10 744-757
- 33 Van Stel H F, Bogaard J M, Rujssenbeek-Nouwens L HM. et al . Multivariable assessment of the 6-min walking test in patients with chronic obstructive pulmonary disease. Am J Resp Crit Care Med. 2001; 163 1567-1571
- 34 Marin J M, Carrizo S J, Gascon M. et al . Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001; 163 1395-1399
- 35 Steele B. Timed walking tests of exercise capacity in chronic cardiopulmonary illness. J Cardiopulm Rehabil. 1996; 16 25-33
- 36 Redelmeier D A, Bayoumi A M, Goldstein R S. et al . Interpretating small differences in functional status: the six minute test in chronic lung disease patients. Am J Respir Crit Care Med. 1997; 155 (4) 1278-1282
- 37 Guyatt G H, Thompson P J, Berman L B. et al . How should we measure function in patients with chronic heart and lung disease?. J Chronic Dis. 1985; 38 517-524
- 38 Mak V HF, Bugler J R, Roberts C M. et al . Effect of arterial oxygen desaturation on six minute walk distance, perceived effort, and perceived breathlessness in patients with airflow limitation. Thorax. 1993; 48 33-38
- 39 O'Donnel D E, McGuire M, Samis L. et al . The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. Am J Respir Crit Care Med. 1995; 152 2005-2013
- 40 O'Donnel D E, McGuire M, Samis L. et al . General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. Am J Respir Crit Care Med. 1998; 157 1489-1497
- 41 McGavin R, Artvinli M, Naoe H . et al . Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. BMJ. 1978; 2 241-243
- 42 Wijkstra P J, Ten Vergert E M, van der Mark T W. et al . Relation of lung function, maximal inspiratory pressure, dyspnea, and quality of life in patients with exercise capacity in patients with chronic obstructive pulmonary disease. Thorax. 1994; 49 468-472
- 43 Engström C P, Persson L O, Larsson S. et al . Health-related quality of life in COPD: why both disease-specific and generic measures should be used. Eur Respir J. 2001; 18 69-76
- 44 Curtis J R, Deyo R A, Hudson L D. Health-related quality of life among patients with chronic obstructive pulmonary disease. Thorax. 1994; 49 162-170
- 45 King B, Cotes JE. Relation of lung function and exercise capacity to mood and attitudes to health. Thorax. 1989; 44 402-409
- 46 Siafakas N M, Vermeire P, Pride N B. et al . Optimal assessment and management of chronic obstructive pulmonary disease (COPD): the European Respiratory Society Task Force. Eur Resp J. 1995; 8 1398-1420
- 47 Ries A L. Position paper of the American Association of Cardiovascular and Pulmonary Rehabilitation: scientific basis of pulmonary rehabilitation. J Cardiopulmonary Rehabil. 1990; 10 418-441
- 48 Fishman A P. Pulmonary rehabilitation research. Am J Respir Crit Care Med. 1994; 149 825-833
- 49 ACCP/AACVR Pulmonary Rehabilitation Panel . Joint ACCP/AACVR evidence-based guidelines: pulmonary rehabilitation. American College of Chest Physicians American Association of Cardiovascular and Pulmonary Rehabilitation. Chest. 1997; 112 1363-1396
- 50 Lacasse Y, Wong E, Guyatt G H. et al . Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. Lancet. 1996; 348 1115-1119
- 51 Wijkstra P J, Van Altena R, Kraan J. et al . Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. Eur Respir J. 1994; 7 269-273
- 52 Ries A L, Kaplan R M, Limberg T M. et al . Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in patients with chronic obstructive pulmonary disease. Ann Intern Med. 1995; 122 823-832
- 53 Casaburi R. Deconditioning. In: Fishman AP, ed. Pulmonary rehabilitation: lung biology in health and disease (Vol. 91). New York: Marcel Dekker 1996: 213-230
- 54 Maltais F, LeBlanc P, Jobin J. et al . Peripheral muscle dysfunction in chronic obstructive pulmonary disease. Clin Chest Med. 2000; 21 665-677
- 55 Belman M J, Kendregan B A. Exercise training fails to increase skeletal muscle enzymes in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1981; 123 256-261
- 56 Maltais L, LeBlanc P, Simard C. et al . Skeletal muscle adaptation to endurance training in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996; 154 442-447
- 57 ERS Task Force on Standard of Clinical Exercise Testing. European Respiratory Society . Clinical exercise testing with reference to lung diseases: indications, standardization and interpretation strategies. Eur Respir J. 1997; 10 (11) 2662-2689
- 58 Ambrosino N. Field tests in pulmonary disease. Thorax. 1999; 54 191-193
- 59 Griffiths T, Gregory S E, Ward S A. et al . Effects of domiciliary exercise training on ventilatory and gas-exchange kinetics in patients with severe COPD. Eur Resp J. 1995; 8 502
- 60 Haas F, Salazar-Schicchi J, Axen K. Desensitization to dyspnea in chronic obstructive pulmonary disease. In: Casabury R, Petty TL, eds. Principles and practice of pulmonary rehabilitation. Philadelphia: WB Saunders 1993: 241-251
- 61 Jansen H J, Zeidler D. Die lungenfunktionelle Abklärung des pulmonalen Resektionsumfangs in der Thoraxchirurgie. Atemw-Lungenkrkh. 1999; 25 138-150
- 62 Schulz C, Emslander H P, Riedel M. Beurteilung der funktionellen Operabilität von Patienten mit Bronchialkarzinom. Pneumologie. 1999; 53 337-347
- 63 Schulz C, Riedel M, Gillissen A. et al . Präoperative Identifizierung des pulmonalen Risikopatienten vor Lungenresektion. Atemw-Lungenkrkh. 1998; 24 205-214
- 64 Wyser C, Stulz P, Soler M. et al . Prospective evaluation of an algorithm for the functionell assessment of lung resection candidates. Am J Respir Crit Care Med. 1999; 159 1450-1456
- 65 Bolliger C T, Jordan P, Soler M. et al . Exercise capacity as a predictor of postoperative complications in lung resection candidates. Am J Respir Crit Care Med. 1995; 151 1472-1480
- 66 Bollinger C T, Perruchoud A P. Functional evaluation of the lung resection candidate. Eur Respir J. 1998; 11 198-212
- 67 Kearney D J, Lee T H, Reilly J J. et al . Assessment of operative risk in patients undergoing lung resection. Importance of predicted pulmonary function. Chest. 1994; 105 753-759
- 68 Thomas M, Gatzemeier U, Georg R. et al . Empfehlungen zur Diagnostik des Bronchialkarzinoms. Deutsche Gesellschaft für Pneumologie. Pneumologie. 2000; 54 361-371
- 69 BTS Guidelines . Guidelines on the selection of patients with lung cancer for surgery. Thorax. 2001; 56 89-108
- 70 Miyoshi S, Nakahara K, Ohno K. et al . Exercise tolerance in lung cancer patients: the relationship between exercise capacity and post-thoracotomy hospital mortality. Ann Thorax Surg. 1987; 44 487-490
- 71 Miller J L, Grossman G D, Hatcher C R. Pulmonary function test criteria for operability and pulmonary resection. Surg Gynecol Obstetr. 1981; 153 893-895
- 72 Nakagawa K, Nakahara K, Miyoshi S. et al . Oxygen transport during incremental exercise load as a predictor of operative risk in lung cancer patients. Chest. 1992; 101 1369-1375
- 73 Nakahara K, Miyoshi S, Nakagawa K. A method for predicting postoperative lung function and its relation to postoperative complications in patients with lung cancer.
- 74 Olsen G N, Weiman D S, Bolton J W. et al . Submaximal invasive exercise testing and quantitative lung scanning in the evaluation for tolerance of lung resection. Chest. 1989; 95 267-273
- 75 Pierce R J, Pretto J J, Rochford P D. et al . Lobar occlusion in the preoperative assessment of patients with lung cancer. Br J Dis Chest. 1986; 80 27-36
- 76 Bagg L R. The 12-min walking distance; its use in the pre-operative assessment of patients with bronchial carcinoma before lung resection. Respiration. 1984; 46 342-345
- 77 Markos J, Mullan B P, Hillman D R. et al . Preoperative assessment as a predictor of mortality and morbidity after lung resection. Am Rev Respir Dis. 1989; 139 902-910
- 78 Holden D A, Rice T W, Stelmach K. et al . Exercise testing, 6-min walk, and stair climbing in the evaluation of patients at high risk for pulmonary resection. Chest. 1992; 102 1774-1779
- 79 Szekelay L A, Oelberg D A, Wright C. et al . Preoperative predictors of operative morbidity and mortality in COPD patients undergoing bilateral lung volume reduction surgery. Chest. 1997; 111 550-558
- 80 Chatila W, Furukuwa S, Criner G J. Acute respiratory failure after lung volume reduction surgery. Am J Respir Crit Care Med. 2000; 162 1292-1296
- 81 Teschler H, Stamatis G, Fahrat A A. et al . Funktionelle Ergebnisse der chirurgischen Lungenvolumenreduktion beim schweren Lungenemphysem. DMW. 1996; 121 1248-1254
- 82 Stamatis G. Chirurgie des Lungenemphysems. Atemw-Lungenkrkh. 2000; 26 69-77
- 83 Thurnheer R, Engel H, Weder W. et al . Role of lung perfusion scintigraphy in relation to chest computed tomography and pulmonary function in the evaluation of candidate for lung volume reduction surgery. Am J Respir Crit Care Med. 1999; 159 301-310
- 84 Flaherty K R, Kazerooni E A, Curtis J L. et al . Short-term and long-term outcomes after bilateral lung volume reduction surgery: prediction by quantitive CT. Chest. 2001; 119 1337-1346
- 85 Gelb A F, McKenna R J, Brenner M. et al . Lung function 5 years after lung volume reduction surgery for emphysema. Am J Respir Crit Care Med. 2001; 163 1562-1566
- 86 Geddes D, Davies M, Koyama H . et al . Effect of lung volume reduction surgery in patients with severe emphysema. N Engl J Med. 2000; 343 239-245
- 87 Naunheim K S, Kaiser L R, Bavaria J E. et al . Long-term survival after thoracoscopic lung volume reduction: a multiinstitutional review. Ann Thorac Surg. 1999; 68 2026-2032
- 88 American Thoracic Society . Official statement of the American Thoracic Society: Lung volume reduction surgery. Am J Respir Crit Care Med. 1996; 154 1151-1152
- 89 Demertzis S, Schäfers H J, Wagner T OF. et al . Bilaterale Lungenvolumenreduktion bei schwerem Emphysem. DMW. 1996; 121 427-433
- 90 Cooper J D, Patterson G A. Lung-volume reduction surgery for severe emphysema. Chest Surg Clin North Amer. 1995; 5 815-830
- 91 Cooper J D, Trulock E P, Triantafillou A N. et al . Bilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg. 1995; 109 106-119
- 92 Eugene J, Ott R A, Gogia H S. et al . Videothoracic surgery for treatment of end-stage bullous emphysema and chronic obstructive disease. Amer Surg. 1995; 61 934-936
- 93 Little A G, Swain J A, Nino J J. et al . Reduction pneumoplasty for emphysema. Ann Surg. 1995; 222 365-374
- 94 Criner G J, Cordova F C, Furukawa S. et al . Prospective randomized trail comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999; 160 2018-2027
- 95 Hamacher J, Bloch K, Stammberger U. et al . Two years outcome of lung volume reduction surgery in different morphologic emphysema types. Ann Thorac Surg. 1999; 68 1792-1798
- 96 Teschler H. Lungenvolumenreduktion, wann und bei wem? Tagungsbericht „Update COPD”. Herbsttagung der Rheinisch-Westfälischen Vereinigung für Lungen- und Bronchialheilkunde November 2000. Pneumologie. 2001; 55 202-203
- 97 Shrager J B, Friedberg J S, Kaiser L R. Lung volume reduction surgery. Sem Resp Crit Care Med. 1999; 20 1-14
- 98 Cooper J D, Lefrak S S. Lung-reduction surgery: 5 years on. Lancet. 1999; 353 (Suppl 1) 26-27
- 99 Armstrong P W, Moe G W. Medical advances in the therapy of congestive heart failure. Circulation. 1993; 88 2941-2952
- 100 Australian-New Zealand Heart Failure Research Collaborative Group. . Effects of carvedilol, a vasodilator beta-blocker, in patients with congestive heart failure due to ischemic heart disease. Circulation. 1995; 92 212-218
- 101 Provenier F, Jordoens S. Evaluation of 6-minute walking test in patients with single chamber rate response pacers. Br Heart J. 1994; 72 192-196
- 102 Bittner V, Weiner D H, Yusuf R. et al . Prediction of mortality and morbidity with a 6-min walk test in patients with left ventricular dysfunction. JAMA. 1993; 270 1702-1707
- 103 Cahalin L P, Mathier M A, Semigran M J. et al . The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest. 1996; 110 325-332
- 104 Roul G, Germain P, Bareiss P. Does the 6-min walk test predict the prognosis in patients with NYHA class II or III in chronic heart failure?. Am Heart J. 1998; 136 449-457
- 105 Faggiano P, D'Aloia A, Gualeni A. et al . Assessment of oxygen uptake during the 6-minute walking test in patients with heart failure: preliminary experience with a portable device. Am Heart J. 1997; 134 203-207
- 106 Riley M, McParland J, Stanford C F. et al . Oxygen consumption during corridor walking testing in chronic cardiac failure. Eur Heart J. 1992; 13 789-793
- 107 Peeters P, Mets T. The 6-min walk as an appropriate exercise test in elderly patients with chronic heart failure. J Gerontol A Biol Sci Med Sci. 1996; 51 M147-M151
- 108 Milligan N P, Havey J, Dossa A . Using a 6-min walk test to predict outcomes in patients with left ventricular dysfunction. Rehabil Nurs. 1997; 22 177-181
- 109 Zugck C, Kruger C, Durr S. et al . Is the 6-minute walk test a reliable substitute for peak oxygen uptake in patients with dilated cardiomyopathy?. Eur Heart J. 2000; 21 540-549
- 110 Morales F J, Montemayor T, Martinez A. Shuttle versus six-minute walk test in the prediction of outcome with chronic heart failure. Int J Cardiol. 2000; 76 101-105
- 111 Lucas C, Stevenson L W, Johnson W. et al . The 6-min walk and peak oxygen consumption in advanced heart failure: aerobic capacity and survival. Am Heart J. 1999; 138 618-624
- 112 Opasich C, Pinna G D, Mazza A. et al . Six-minute walking performance in patients with moderate-to-severe heart failure; is it a useful indicator in clinical practice?. Eur Heart J. 2001; 22 488-496
- 113 Langenfeld H, Schneider B, Grimm W. et al . The six-minute walk - an adequate exercise test for pacemaker patients?. Pacing Clin Electrophysiol. 1990; 13 1761-1765
- 114 Rozkovec A, Papouchado M, James M A. et al . The relationship of symptoms to performance in paced patients with breathlessness. Eur Heart J. 1989; 10 63-69
- 115 Weisman I M, Zeballos R J. An integrated approach to the interpretation of cardiopulmonary exercise tests. In: Weisman IM, Zeballos RJ, eds. Clinical exercise testing; Clinics in Chest Medicine. Philadelphia: W. B. Saunders 1994
- 116 Wasserman K, Hansen J E, Sue D Y. et al .Principles of Exercise Testing and Interpretation. Lea & Febiger 1994
- 117 Beaumont A, Cockroft A, Guz A. A self paced treadmill walking test for breathless patients. Thorax. 1985; 40 459-464
- 118 Kirsten D, Jörres R, Magnussen H. Indikation und Durchführung des 6-Minuten-Lauftests in der Pneumologie. Pneumologie. 1997; 51 33-35
Prof. Dr. med. H. Morr
Pneumologische Kinik Waldhof-Elgershausen
35753 Greifenstein
Email: harald.morr.waldhof@t-online.de