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DOI: 10.1055/s-2002-33805
Intracellular Calcium Involved in the Long-Term Potentiation Induced by Securinine in Dentate Gyrus of Anesthetized Rats
Publikationsverlauf
Received: October 5, 2001
Accepted: March 12, 2002
Publikationsdatum:
09. September 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200208/lookinside/thumbnails/10.1055-s-2002-33805-1.jpg)
Abstract
The effect of nimodipine on securinine-induced long-term potentiation in rat hippocampus was studied. The rise of intracellular calcium during the induction of long-term potentiation was measured using Fura-2/AM - a Ca2+ fluorescent chelator. Results showed that intracerebroventricular injection of nimodipine (4 nmol) blocked the induction of long-term potentiation elicited by securinine (0.4 pmol) and high-frequency stimulation (p < 0.05), but 2-amino-5-phosphonovaleric acid (5 nmol) had no inhibitory effect on securinine-induced long-term potentiation. In addition, securinine-induced intracellular calcium increment was inhibited by nimodipine (10-6 mol · L-1, p < 0.01), but not by 2-amino-5-phosphonovaleric acid (10-6 mol · L-1, p > 0.05).
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Zhang Jun-tian
Department of Pharmacology
Institute of Materia Medica
Chinese Academy of Medical Sciences & Peking Union Medical College
1# Xian Nong Tan Street
Beijing 100050
P.R. China
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